Oligosaccharide mimics

Aminosugar acid Aminosugar HBTU Oligosaccharide mimic 89 2005AGE2096... 

K. Sasaki, Y. Nishida, T. Tsurumi, H. Uzawa, H. Kondo, and K. Kobayashi, Facile assembly of cell surface oligosaccharide mimics by copolymerization of carbohydrate modules, Angew. Chem. Int. Ed, 41 (2002) 4463 1467. 

Halkes KM, St Hilaire PM, Crocker PR, Meldal M, Glycopeptides as oligosaccharide mimics high affinity sialopeptide ligands for sialoadhesin from combinatorial libraries, J. Comb. Chem., 5(1) 18-27, 2003. 

Oligosaccharide mimics of the O-antigens of many bacterial pathogens, including E. coli [236], Helicobacter pylori [237], Shigella flexneri [238,239] and Vibrio cholerae [240,241] have been synthesized and evaluated for use in antibacterial vaccines (O Fig. 16). 

Synthetic studies on oligosaccharide mimics carrying sulfur atoms in the pyranose rings 06Y766. 

The 2-acetamido derivative of DNJ (35) has been prepared by reaction of azide followed by reduction and acetylation of the corresponding 2,3-anhydro-o-mannose derivative. Compound 35 was incorporated into oligosaccharide mimics of sialyl Le and sialyl Le, ... 

Keywords Binding kinetics Drug discovery Lead optimization MyeUn-associated glycoprotein (MAG) Oligosaccharide mimics Sialosides Siglecs... 

Table 6 Relative inhibitory potencies (rIPs) of oligosaccharide mimics. The rIP of each substance was calculated by dividing the IC50 of the reference compound 67 by the IC50 of the compound of interest. This results in rIPs above 1.00 for derivatives binding better than 67 and rIPs below 1.00 for compounds with a lower affinity. OSE 2-(trimethylsilyl)ethoxy...

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