Hedgehog signaling

McMahon We can play around with the IGF signalling system and get a smaller skeleton that way. We can also get a small skeleton by manipulating the Hedgehog signalling system. What isn t known is how those two systems talk to one another. I think it is an excellent system to study. If you want to pick a mammalian system, you want to have it such that the arrangement is easy to determine. It is a very stereotypical arrangement of growth and cell movements. 

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Basal cell carcinoma Mutation PTCH, SMO SMO (hedgehog signaling pathway) Vismodegib... 

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Sonic Hedgehog signaling Shh, PTC-1, Smoothened, GSK3/ , PKA, SUFU, GLl-1,2,3, DYRKl, Gdc2/GyclinB Cancer, Parkinson s... 

The Wingless and Hedgehog signals control which cell types form in which positions, creating additional boundaries beyond those established by pair-rule proteins. Even... 

Hedgehog Signaling, Which Requires Two Transmembrane Proteins, Relieves Repression of Target Genes... 

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