Heavy metal poisoning, antidotes

Therapeutic Function Antidote in heavy metal poisoning Chemical Name N-(2-Mercapto-1-oxopropyl)glycine Common Name Mercamidum... 

Use antidote (heavy metal poisonings), antirheumatic (PCA and Morbus Wilson)... 

Benfey, Otto Th. Spinach as an alchemical antidote to heavy metal poisoning. Kagakushi J Japanese Soc Hist Chem 15 (1981) 8-12. 

I heavy metal ions with electrostatic interactions yO- and are used as antidotes in heavy metal poisoning (and I though all I had to do was Q turn off the radio ). 

The first chelating agent developed as an antidote to a heavy metal poison was 2,3-dimereaptopropanol (dimercaprol, British Anti-Lewisite, BAL). Originally intended for use on victims of the arsenical vesicant poison gas Lewisite52, it has since proved efficacious in the treatment of antimony, gold and mercury poisoning as well as... 

Detoxication of Metals. Pectins or pectin derivatives have been proposed as antidotes for heavy metal poisoning for nearly 200 years. Kertesz (9) has reviewed the early work in this area. Pectin complexes lead so strongly as to quantitatively remove it from solution. Absorption 6f lead, arsenic, and selenium by several animal species has been reduced by pectin- or apple-containing diets. Use of pectin as a prophylactic agent in lead poisoning continues to be of interest. Bondarev (88) recently reported an increase in excretion and a decrease in bone accumulation of lead when rats fed 6 mg/day of lead also received 72-432 mg/day of low ester pectin. Paskins-Hurlburt et al. (89) achieved an 87% decrease in lead absorption by pectate fed rats. These studies bear out the early observations of Fellenburg (see 9, p. 572), who concluded that pectin of decreased ester content would have an enhanced ability to complex metals. 

Ro 1-7977 Chemet ) is a CHELATING AGENT, used as an ANTIDOTE for heavy metal poisoning (Pb. As, Hg) and as a diagnostic agent. A Tc derivative is used in renal scintigraphy. 

Use Medicine (antidote in heavy-metal poisoning), in foods to complex trace heavy metals, as a preservative, and to retain color and flavor antigushing agent in fermented malt beverages. (For restrictions on food uses, see FDA regulations.)... 

Aposhian, H.V. 1983. DMSA and DMPS Water-soluble antidotes for heavy metal poisoning. Annu. Rev. Pharmacol. Toxicol. 23 193-215. 

Table VIII-3-2. Signs, Symptoms, and Interventions or Antidotes for Heavy Metal Poisoning...

Table VIII-3-2 lists the common heavy metal poisons with their most common sources, signs, and j symptoms and potential modes of intervention and/or antidotes. j...

Aposhian HV (1983). DMSA and DMPS - water soluble antidotes for heavy metal poisoning. AnnuRev Pharmacol Toxicol, 23, 193-215. 

D-penicillamine (D-3-mercaptovaline, Cuprimine), a breakdown product of penicillin, was, after the discovery of its chelating properties of copper ion (Fig. 2-6), introduced as an antidote to copper poisoning. It was also found useful in the treatment of Wilson s disease, where excess copper accumulation causes liver cell damage. Heavy metal poisoning treatment is not limited to copper. Mercury and lead poisoning are also successfully reversed. Formation of cysteine calculi (cystinuria) can also be reversed with penicillamine by forming a soluble disulfide compound. 

Dimercaprol (HSCH2CHSHCH2OH) is a complexing agent developed during World War I as an antidote to arsenic-based poison gas and used today to treat heavy-metal poisoning. Such an agent binds and removes the toxic element from the body. 

Aposhian el al- toe. cit. ]981). therap cat Antidote (to heavy metal poisoning). 

Succimen A mercaptodicarhoxyhc acid used as an antidote to heavy metal poisoning because it forms strong chelates with them. [NIH]... 

B. The medical treatment of occupational toxic illness should follow the general principles outlined earlier in this section and in Sections I and II of this book. In particular, the use of specific antidotes should be undertaken in consultation with a regional poison control center ([800] 222-1222) or other specialists. This is particularly true before chelation therapy is initiated for heavy metal poisoning. 

Explain how egg white ean serve as an emergency antidote for heavy-metal poisoning. 

Heavy-metal poisoning is treated by administering chelating agents—substances that combine with the metal ions and hold them very tightly. One effective antidote is the chelating agent ethylenediaminetetraacetic add, or EDTA, which will chelate all heavy metals except mercury. 

Uses Chelating agent antidote to arsenic, gold, and mercury poisoning antidote to Lewisite detoxicant for heavy metal poisoning... 

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