Headache calcium-channel blockers

The calcium channel blockers have been associated with both prolonged pregnancy and decreased neonatal morbidity.36,42 when compared with P-mimetics (e.g., terbutaline) and magnesium, they show better neonatal outcome and a lower incidence of serious maternal side effects.42 Potential minor maternal adverse effects include headache, flushing, dizziness, and transient hypotension.41... 

The primary problems associated with the calcium channel blockers are related to the peripheral vasodilation produced by these agents. Headache, flushing or... 

Diphenylalkylamines Verapamil [ver AP a mill] is the only member of this class that is currently approved in the United States. Verapamil is the least selective of any calcium channel blocker, and has significant effects on both cardiac and vascular smooth-muscle cells. It is used to treat angina, supraventricular tachyarrhythmias, and migraine headache. 

CALCIUM CHANNEL BLOCKERS IMATINIB t plasma concentrations of imatinib when is co-administered with dilti-azem, nifedipine or verapamil, t risk of toxicity (e.g. abdominal pain, constipation and dyspnoea) and of neurotoxicity (e.g. taste disturbances, dizziness, headache, paraesthesias and peripheral neuropathy) Due to inhibition of hepatic metabolism of imatinib by the CYP3A4 isoenzymes by diltiazem Monitor for clinical efficacy and for the signs of toxicity listed along with convulsions, confusion and signs of oedema (including pulmonary oedema). Monitor electrolytes and liver function, and for cardiotoxicity... 

Throbbing headache, facial warmth and flushing, and dizziness are minor complaints associated with the use of calcium channel blockers these effects are beheved to be caused by inhibitory actions on smooth muscle (20). Palpitation, muscle cramps, and pedal edema also occur (21-27). Dizziness, facial flushing, leg edema, postural hypotension, and constipation have been reported in up to one-third of patients. They are rarely severe and often abate on continued therapy. More serious adverse effects, mainly those affecting cardiac conduction, are much less common, and only rarely is withdrawal necessary. 

Felodipine is a dihydropyridine derivative with diuretic properties (1). Its diuretic properties are not unique but are shared by other dihydropyridines. Its vasodilator-related adverse effects include flushing, headache, and tachycardia (2,3). Reduced arterial oxygen saturation has been seen in patients given intravenous felodipine for pulmonary hypertension (4,5). Along with amlodipine, but unlike other calcium channel blockers, felodipine may be safer in severe chronic heart failure accompanied by angina or hypertension. 

Calcium channel blockers Group toxicity dihydropyridines can cause headache, ankle edema, gingival hyperplasia and flushing nondihydropyridine can cause bradycardia, constipation, gingival hyperplasia, and AV block ... 

Most side effects of the calcium channel blockers are related to their mechanism of action. Verapamil and diltiazem can both cause sinus bradycardia and may worsen CHF. Constipation has been associated with verapamil use. The dihydropyridines often cause symptoms associated with vasodilatation, such as facial flushing, peripheral edema, hypotension, and headache. Because dihydropyridines are potent vasodilators, they can cause reflex tachycardia, which may precipitate palpitations, worsening angina, or Ml. Lastly, all calcium channel blockers can cause Gl complaints and fatigue. 

A 25-year-old woman with a history of migraine headaches was started on a calcium channel blocker 6 months ago for prophylaxis therapy. She now reveals that she has been having problems with constipation since starting therapy. In addition, she says that her gums are "overgrowing." PMH Depression and diabetes. Which calcium channel blocker is the most likely cause of her side effects ... 

Verapamil, proprietaiy name Calan, is a calcium channel blocker that is effective in the treatment of various cardiovascular disorders, including angina (classical and variant), arrhythmias (paroxysmal supraventricular tachycardia), atrial flutter, atrial fibrillation, hypertrophic cardiomyopathy (idiopathic hypertrophic subaortic stenosis), hypertension, congestive heart failure, and Raynaud s phenomenon, along with the preservation of ischemic myocardium and the treatment of migraine headaches. 

Headaches Beta blockers, calcium channel blockers. Disease-specific cautions (i.e., beta-blockers... 

Verapamil, the preferred calcium channel blocker for the prevention of cluster headaches, is effective in approximately 70% of patients." The... 

CALCIUM CHANNEL BLOCKERS Dihydropyridine headache, ankle edema. 

Adverse effects of class II calcium channel blockers are reflex tachycardia, headache, flushing, palpitations and ankle oedema. 

Adverse reactions to tlie calcium channel blocMiig dni usually are not serious and rarely require discontinuation of tlie drug therapy. The more conunon adverse reactions include dizziness, li it-headedness, nausea, diarrhea, constipation, peripheral edema, headache, bradycardia, flushing, dennatitis, sMii rash, and nervousness. See tlie Summary Drug Table Antianginal Dni for a more specific listing of tlie adverse reactions of tlie calcium channel blockers. 

Monitoring for major adverse effects should be undertaken they include headache and dizziness with nitrates fatigue and lassitude with /J-blockers and peripheral edema, constipation, and dizziness with calcium channel antagonists. 

Verapamil (Table 1), the first slow channel calcium blocker synthesized to selectively inhibit the transmembrane influx of calcium ions into cells, lowers blood pressure in hypertensive patients having good organ perfusion particularly with increased renal blood flow. Sustained-release verapamil for once a day dosing is available for the treatment of hypertension. Constipation is a prominent side effect. Headache, dizziness, and edema are frequent and verapamil can sometimes cause AV conduction disturbances and AV block. Verapamil should not be used in combination with -adrenoceptor blockers because of the synergistic negative effects on heart rate and contractile force. 

---