Pedal edema

Calcium channel Dihydropyridine Pedal edema, headache... 

Potassium channel openers Hypertrichosis (minoxidil) lupus-like reactions and pedal edema (hydralazine)... 

Peripheral edema (e.g., pedal edema, which is swelling of feet and ankles)... 

Chest Basilar crackles, inspiratory wheezes CV S, S2 normal, no S3 MS/Exts 2+ pedal edema... 

Exts Trace pedal edema bilaterally decreased sensation in feet to light touch no lesions... 

Common side effects include nausea, vomiting, sedation (highest with apomorphine), pedal edema, orthostatic hypotension (highest with pramipexole and cabergoline), and... 

Gabapentin Dizziness Fatigue Somnolence Ataxia Pedal edema Weight gain... 

IM, Subcutaneous-. Epigastric discomfort, dry mouth, diarrhea, flatulence NflSfll Itching of earlobes, pedal edema, rash, diaphoresis... 

Notify the physician of acne, nausea, pedal edema, orvomiting... 

Adverse effects include nausea, constipation, hypotension, flushing, dizziness, vertigo, pedal edema, nervousness and paraesthesias. 

A 31-year-old white man with depression, hepatitis C, and cirrhosis of the liver was hospitalized for alcohol detoxification. He had taken methadone 50 mg bd for opium dependence for 6 months. He developed bilateral pedal edema and 27 kg weight gain. There was no ascites, portal hypertension, or congestive heart failure. Most of his laboratory tests were within the reference ranges, except for reduced prothrombin time and platelet count. After stopping alcohol, his methadone dose was reduced to 60 mg/day his edema resolved 15 days later. When the dose of methadone was increased to 70 mg/day there was a progressive increase in the edema. When methadone was withdrawn his edema completely resolved and he lost 8 kg in 2 weeks. 

Throbbing headache, facial warmth and flushing, and dizziness are minor complaints associated with the use of calcium channel blockers these effects are beheved to be caused by inhibitory actions on smooth muscle (20). Palpitation, muscle cramps, and pedal edema also occur (21-27). Dizziness, facial flushing, leg edema, postural hypotension, and constipation have been reported in up to one-third of patients. They are rarely severe and often abate on continued therapy. More serious adverse effects, mainly those affecting cardiac conduction, are much less common, and only rarely is withdrawal necessary. 

The tuber of Sechium edule (chayote) is valued as a potent diuretic by Latin American populations. Its use as a decoction by a pregnant woman suffering from pedal edema may have been the cause of a severe case of hypokalemia (14). 

A preliminary study of the thrombopoietic effect of oprelvekin (50 pg/kg/day for 21 days) in patients with refractory immune thrombocjrtopenic purpura was halted, since all of the first seven patients had adverse effects without significant changes in the platelet count (3). Adverse effects consisted of conjunctival injection, diffuse aches and joint pains, marked pedal edema, pete-chiae, and mild anemia. In addition, one patient had a neuropathy, which resolved more than 1 month after oprelvekin withdrawal. 

Bone marrow depression, pulmonary, periorbital and pedal edema Bone marrow depression anorexia neutropenia anemia confusion depression renal toxicity possible hepatic injury facial and peripheral edema cardiac arrhythmias rhabdomyolysis... 

Peripheral edema is a cardinal finding in heart failure. Edema usually occurs in dependent parts of the body and thus is seen as ankle or pedal edema in ambulatory patients, although it may be manifested as sacral edema in bedridden patients. Adults typically have a 10-lb fluid weight gain before trace peripheral edema is evident therefore, patients with acute heart failure may have no clinical evidence of systemic congestion except weight gain. 

Sleep disturbance Other Fatigability Oily skin Pedal edema Seborrhea Weight loss... 

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