Pregnancy prolonged

Contraindications Hypersensitivity to morphine sulfate or any component of the formulation, increased intracranial pressure, severe respiratory depression, severe hepatic or renal insufficiency, pregnancy (prolonged use or high dosages near term)... 

In experiments on patients with breast cancer, it was found that up to a two-fold increase in serum /3-D-glucuronidase followed surgery, pregnancy, prolonged estrogen or cortisone therapy, etc.206 The /3-D-glucu-ronidase rise was usually accompanied by a fall in serum esterase, in both animal and human experiments. A rise in urinary ketosteroid excretion usually paralleled the changes, in man. 

Terbutaline has been shown to prolong pregnancy but has not been associated with decreased neonatal morbidity.36 It is contraindicated for use in women with preexisting cardiac arrhythmia. Potentially serious adverse effects include pulmonary edema, cardiac arrhythmia, or myocardial ischemia in the mother. Reported fetal and neonatal adverse effects include tachycardia, hyperglycemia, and hyperinsulinemia.41... 

Indomethacin prolongs pregnancy but has not been independently associated with decreased neonatal morbidity.36 It may be of particular benefit in women with hydramnios.36 Avoid use in women with a history of severe renal or hepatic... 

The calcium channel blockers have been associated with both prolonged pregnancy and decreased neonatal morbidity.36,42 when compared with P-mimetics (e.g., terbutaline) and magnesium, they show better neonatal outcome and a lower incidence of serious maternal side effects.42 Potential minor maternal adverse effects include headache, flushing, dizziness, and transient hypotension.41... 

Antibiotics are warranted in patients who present with high fevers, severe bloody diarrhea, prolonged illness (greater than 1 week), pregnancy, and immunocompromised states, including human immunodeficiency virus infection. 

Renal/Hepatic function impairment Renal and hepatic dysfunction may cause a prolonged duration and cumulative effect smaller doses may be necessary. Meperidine In patients with renal dysfunction, normeperidine (an active metabolite of meperidine) may accumulate, resulting in increased CNS adverse reactions. Pregnancy Category C, Category B, (oxycodone). 

Pregnancy Category B. Category D in prolonged use or in high doses at term). 

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