Stem cells, haemopoietic

Schoeters GER, Vanderborght OLJ. 1983. Relative effectiveness of241 Am vs 226Ra approached by haemopoietic stem cell studies in various bone marrow sites of contaminated mice. Health Phys 44(Suppl. l) 555-570. 

Graham GJ, Wright EG, Hewick R, et al. Identification and characterization of an inhibitor of haemopoietic stem cell proliferation. Nature 1990 344(6265) 442-444. 

Figure 10.4 Stages in the differentiation of haemopoietic stem cells, yielding mature erythrocytes. The EPO-sensitive cells are indicated. Each cell undergoes proliferation as well as differentiation thus, greater numbers of the more highly differentiated daughter cells are produced. The proliferation phase ends at the reticulocyte stage each reticulocyte matures over a 2-day period, yielding a single mature erythrocyte...

Henschler R, Glatt HR. 1995. Induction of cytochrome P4501A1 in haemopoietic stem cells by hydroxylated metabolites of benzene. Toxicol In Vitro 9 453-457. 

Dexter TM, Allen TD, Lajtha LG. Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol 1977 91 335-344. 

Figure 17.8 Development of immune cells and erythrocytes in bone marrow from a pluripotent haemopoietic stem cell.

Although the major physiological role of EPO is certainly to promote red blood cell production, EPO mRNA has also been detected in bone marrow macrophages, as well as some multipotential haemopoietic stem cells. Although the physiological relevance is unclear, it is possible that EPO produced by such sources may play a localized paracrine (or autocrine) role in promoting erythroid differentiation. 

Mylotarg (like most other drugs) does induce some side effects, the most significant of which is immunosuppression. This is induced because certain additional (non-cancerous) white blood cell precursors also display the CD-33 antigen on their surface. The immunosuppressive effect is reversed upon termination of treatment, as pluripotent haemopoietic stem cells (Chapter 6) are unaffected by the product. 

European Group for Blood and Marrow Transplantation European Society for Immunodeficiency. Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies Report of the European experience 1968-99. Antoine, C., Muller, S., Cant, A., Cavazzana-Calvo, M., Veys, P., Vossen, J., Fasth, A., Heilmann, C., Wulffraat, N., Seger, R., Blanche, S. et al. (2003). Lancet, 361 (9357) 553-560. 

A.M. Gianni, et al., Granulocyte macrophage colony stimulating factor to harvest circulating haemopoietic stem cells for autotransplantation. Lancet ii 580—584,1989. 

Lorimore, S. A., Pragnell, I. B., Eckmann, L., and Wright, E. G. (1990) Synergistic interactions allow colony formation in vitro by murine haemopoietic stem cells. Leak. Res. 14,481 189. 

V. Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin s disease a randomized trial. Lancet 2002 359 2065 - 2071... 

Anti-glycating effects. It was shown in 1990 that camosine (50-100 mg/kg body weight) increases survival of rodents when it was administered to animals before sub-lethal dose of y-irradiation [5]. Kurella et al. [58] have found that under these conditions viability of haemopoietic stem cells is significantly increased and their colony forming activity is activated as well. These phenomena can be addressed to anti-radical protection of biomacromolecules by camosine, however camosine was additionally found to protect nuclear DNA from oxidative modification induced by hyperoxia, to preserve its native stmcture and to synchronize cell cycle in vitro [59]. Its addition to the medium where fibroblasts were cultivated increased the longevity of cell life and reversed the senescence features of the cells [60]. Moreover, camosine was demonstrated to increase stability of... 

E. Kurella et al., Stimulating effect of carnosine on haemopoietic stem cells. Bull Exp. Biol Med. (Russian) 112(1991)52-53. 

V. Maltseva et al.. Effect of carnosine on the activity of haemopoietic stem cells in irradiated animals. Biochemistry Moscow, 51 (1992) 952-955. 

T-lymphocyte (thymus dependent T-cell) A type of lymphocyte involved in cellular immune reactions and aiding in the production of antibodies. They originate in haemopoietic stem cells, but undergo essential maturation in the thymus gland. They interact with other cells (e.g. B-lymphocytes) and e.g. antigens, lymphokines via receptor sites on their membranes. There are several subsets of T-lymphocytes see cytotoxic T-cells helper T-cells inducer T-cells suppressor T-cells. 

Popat U, Carrum G, Heslop HE. Haemopoietic stem cell transplantation for acute lymphoblastic leukaemia. Cancer Treat Rev 2003 29 3-10. 

Schofield R (1978). The relationship between the spleen colony-forming cell and the haemopoietic stem cell. A hypothesis. Blood Cells, 4, 7-25. 

Worton RG, McCulloch EA and Till JE (1975). Physical separation of haemopoietic stem cells differing in their capacity for self-renewal. J Exp Med, 130, 91-102. 

These modulations suggest that Chlorella vulgaris potentiates chemopreventive action via the perinatal passage of active constituents and/or metabolites. Moreover, Chlorella vulgaris is capable of protecting haemopoietic tissue of whole body-irradiated mice [9]. This protection is seen both in terms of haemopoietic stem cells and the survival of animals. 

Shu Y.X, RuL B. 2002. A key marker defining haemopoietic stem cells. Methodology of pharmacological experiment, 33 393-394. 

Cox MA, Kastrup J, Hrubisko M. Historical perspectives and the future of adverse reactions associated with haemopoietic stem cells cryopreserved with dimethyl sulfoxide. Cell Tissue Bank 2012 13(2) 203-15. 

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