Haemophilus ducreyi

Due to the low specificity of culture and clinical diagnosis, the multiplex polymerase chain reaction has been employed successfully in diagnosing Haemophilus ducreyi. 

Haemophilus ducreyi, a gram-negative bacterium, has been isolated as the causative organism of chancroid, a genital ulcerative disease usually accompanied by inguinal lymphadenitis and bubo formation. Chancroid may possibly spread to other anatomic sites, a clinical feature first discovered by Ducrey in 1889.37... 

Humphreys TL, Baldridge LA, Billings SD, Campbell JJ, Spinola SM. Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyi. Infect Immun 2005 73 3896-902. 

Flaag et al. found that several species of Haemophilus bacteria can be distinguished by MALDI-TOF mass spectrometry and further showed that different strains of Haemophilus ducreyi tend to exhibit specific unique biomarker peaks between 5000 and 15000 Da.60 Lynn et al. observed a few peaks that could distinguish E. coli strains 0 157 and 7G1, though they specifically note that attempts to identify bacteria based on a limited number of biomarkers can lead to errors.61... 

Chancroid (Haemophilus ducreyi infection) 250 mg IM as a single dose. 

Genital ulcer disease caused by Haemophilus ducreyi (chancroid) Single 1 g dose. 

Haemophilus influenzae is a Gram-negative human pathogen that routinely colonizes the upper respiratory tract. Serotype b capsular strains are associated with invasive diseases such as meningitis, septicemia, epiglottises, pneumonia, and emphysema, particularly in infants (1,2). The presence of TV-acetylglucos-amine as a minor component of lipopolysaccharide (LPS) has been reported in H. influenzae type b strain A2 (3) and in the related species Haemophilus ducreyi... 

Schweda, E. K. H., Sundstrom, A. C., Eriksson, L. M., and Lindberg, A. A. (1994) Structural studies of cell envelope lipopolysaccharides from Haemophilus ducreyi strains ITM2665 and ITM4747. J. Biol.Chem. 16, 12,040-12,048. 

The causal agent, Haemophilus ducreyi, normally responds to erythromycin for 7 days or a single dose of ceftriaxone or azithromycin. 

Anonymous DNA Probes with PCR Assay for the Detection and Identification of Haemophilus ducreyi, www. hrinet.org/techtran/technologies/ ducreyi.html. 

Enoxadn, USP. l-Ethyl-6-fluoro-l.4-dihydro-4-oxo-7-(I-piperazinyI)-I,8-naphthyridine-3-carboxylic acid (Pene-irex) is a quinolone with broad-spectrum antibacterial activity that is used primarily for the treaimenl of urinary tract infections and. sexually transmitted diseases. Enoxacin has been approved for the treatment of uncomplicated gonococcal urethritis and has also been shown to be effective in chancroid caused by Haemophilus ducreyi. A single 400-mg dose is used for these indications. Enoxacin is also approved for the treatment of acute (uncomplicated) and chronic (complicated) urinary tract infections. 

Goon, S., Schilling, B., Tullius, M. V., Gibson, B. W., Bertozzi, C. R. (2003). Metabolic incorporation of unnatural sialic acids into Haemophilus ducreyi lipooligosaccharides. Proc. Natl. Acad. Sci. USA, 18, 3089-3094. 

Haemophilus ducreyi 35000HP Escherichia coli 0157H7 Salmonella typhimuriuitL LT2 Vibrio vulnificus YJ016... 

NMPRT enzyme that converts Nm directly into NMN was originally characterized as a product of the nadV gene in Haemophilus ducreyi This organism, as most other members of Pasteurellaceae, lacks the machinery for amidation of the pyridine carboxylate (as well as most other enzymes of NAD synthesis, see Section... 

Several reports of comparative and noncomparative trials of infections caused by Haemophilus ducreyi have shown that a single 1-g dose of azithromycin is 89-100% effective in curing chancroid, and equally effective as 7 days of erythromycin or a single 250-mg dose of I.M. ceftriaxone [225-228]. 

Issoire, C., Casin, I., Perenet, F., Brunat, N., Janier, M., and Perol, Y. (1990). Pilot study of azithromycin in the treament of chancroid caused by Haemophilus ducreyi. Presented at First Conf. Infect. Dis. (Montreal). 

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