Haemophilus ducreyi Chancroid

Genital ulcer disease caused by Haemophilus ducreyi (chancroid) Single 1 g dose. 

Haemophilus ducreyi, a gram-negative bacterium, has been isolated as the causative organism of chancroid, a genital ulcerative disease usually accompanied by inguinal lymphadenitis and bubo formation. Chancroid may possibly spread to other anatomic sites, a clinical feature first discovered by Ducrey in 1889.37... 

Chancroid (Haemophilus ducreyi infection) 250 mg IM as a single dose. 

Enoxadn, USP. l-Ethyl-6-fluoro-l.4-dihydro-4-oxo-7-(I-piperazinyI)-I,8-naphthyridine-3-carboxylic acid (Pene-irex) is a quinolone with broad-spectrum antibacterial activity that is used primarily for the treaimenl of urinary tract infections and. sexually transmitted diseases. Enoxacin has been approved for the treatment of uncomplicated gonococcal urethritis and has also been shown to be effective in chancroid caused by Haemophilus ducreyi. A single 400-mg dose is used for these indications. Enoxacin is also approved for the treatment of acute (uncomplicated) and chronic (complicated) urinary tract infections. 

Several reports of comparative and noncomparative trials of infections caused by Haemophilus ducreyi have shown that a single 1-g dose of azithromycin is 89-100% effective in curing chancroid, and equally effective as 7 days of erythromycin or a single 250-mg dose of I.M. ceftriaxone [225-228]. 

Issoire, C., Casin, I., Perenet, F., Brunat, N., Janier, M., and Perol, Y. (1990). Pilot study of azithromycin in the treament of chancroid caused by Haemophilus ducreyi. Presented at First Conf. Infect. Dis. (Montreal). 

It is effective against most coccus infections. It is better tolerated than sulfanilamide or sulfathiazole. In fact, it is as potent as sulfathiazole and possesses fewer side reactions. It has also been used in the treatment of chancroid due to Haemophilus ducreyi. It may also be used for the prophylaxis of recurrences of rheumatic fever. 

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