Haematologic analysis

Levene AP, Morgan GJ, Davies FE. The use of genetic microarray analysis to classify and predict prognosis in haematological malignancies. Clin Lab Haematol 2003 25 209-220. 

Estevez Diaz-Flores JF, Estevez Diaz-Flores F, Calzadillo Hernandez C, Rodrigrez Rodrigrez EM, Romero Diaz C, Serra-Majem L. Application of linear discriminant analysis to the biochemical and haematological differentiation of opiate addicts from healthy subjects a case-controlled study. Eur J Clin Nutr 2004 58 449-55. 

Clark AD, McKendrick S, Tansey PJ, Franklin IM, Chopra R. A comparative analysis of lipid-complexed and liposomal amphotericin B preparations in haematological oncology. Br J Haematol 1998 103(l) 198-204. 

Martinez-Dalmau A, Fernandez MN, BarboUa L. Haematological toxicity of thiamphenicol analysis of a case with total irreversible bone marrow aplasia and general review of the problem. [Hematologic toxicity of thiamphenicol. Analysis of a case of irreversible total medullary aplasia and general review of the problem.] Sangre (Bare) 1972 17(l) 59-66. 

Haematological tests, urine analysis and other tests should be performed during the clinical trial as specified in the study protocol. 

In a retrospective analysis, the pharmacokinetics of irinotecan were compared between 49 patients who were smokers and 141 who were non-smokers, and who had received intravenous irinotecan 175 to 350 mg/m (or a fixed dose of 600 mg) once every 3 weeks. Clearance of irinotecan was 18% faster in the group of patients who smoked, and these patients also showed more extensive conversion of the active metabolite SN-38 to the inactive glucuronide (SN-38G). Smokers experienced significantly less haematological toxicity than non-smokers (grade 3 to 4 neutropenia 6% versus 38%), possibly as a result of the increased rate of clearance. ... 

A number of other reports similarly describe reversible bone marrow toxicity associated with anaemia, pancytopenia, leucocytopenia and thrombocytopenia in patients given azathioprine with allopurinol, " and in one case a fatality occurred as a result of neutropenia and septicaemia. In a retrospective analysis of 24 patients who had received both azathioprine and allopurinol, 11 developed leucopenia, 7 developed moderate anaemia, and 5 developed thrombocytopenia. Only 14 of the patients had received a greater than two-thirds reduction in their azathioprine dose when allopurinol was started, but despite this, some of these patients still developed haematological toxicity." ... 

Source Courtesy of Haematologic Technologies, Inc., Essex Junction, VT, Research Reagents Catalog, 2004-2005. Inferred from the zymogen, factor XL Based upon analysis of bovine factor VII. 

The method of choice for serum iron analysis has been recommended by the International Committee for Standardization in Haematology (ICSH) [42]. This reference procedure obviates problems that are inherent in convenient automated methods that are precise but inaccurate [43]. In the recommended reference method, iron is released from transferrin with trichloroacetic acid (TCA), which precipitates apotransferrin and other serum proteins that are removed by centrifugation. Fe in the supernatant fluid is reduced to Fe " with thioglycolic (mercaptoacetic) acid, which is then complexed with a chromogenic iron-chelating reagent whose color is proportional to iron concentration. 

FACS analysis of clinical haematological samples in transplantation for cancer... 

FACS ANALYSIS OF CLINICAL HAEMATOLOGICAL SAMPLES CD33FOHi-FL Total 20E4B... 

---