Guided Tumor Ablation

A Step Towards Supraconservative Surgery 103 Interventional Procedures for the Locoregional Treatment of Breast Cancer 105 Percutaneous Imaging-Guided Tumor Ablation 105 Intraarterial Infusion Chemotherapy 106 References 106... 

In past decades, a variety of treatment modalities have been proposed in the battle against breast cancer. Among these therapies, minimally invasive imaging-guided tumor ablation and intraarterial chemotherapy are approaches that deserve further consideration. 

Cline HE, Hynynen K, Watkins RD, Adams WJ, Schenck JF, Ettinger RH, Freund WR, Vetro JP, Jolesz FA (1995) Focused US system for MR imaging-guided tumor ablation. Radiology 194 731-737... 

Robotic System for Intraoperative US-Guided Hepatic Tumor Ablation... 

Boss A, Clasen S, Kuczyk M, Anastasiadis A, Schmidt D, Claussen CD, Schick F, Pereira PL (2005) Radiofrequency ablation of renal cell carcinomas using MR-guidance initial results. Rofo 177 1139-1145 Brown SD, Vansonnenberg E, Morrison PR, Diller L, Sham-berger RC (2005) CT-guided radiofrequency ablation of pediatric Wihns tumor in a solitary kidney. Pediatr Radiol 35 923-928... 

Zagoria RJ, Hawkins AD, Clark PE, Hall MC, Matlaga BR, Dyer RB, Chen MY (2004) Percutaneous CT-guided radiofrequency ablation of renal neoplasms factors influencing success. AJR Am J Roentgenol 183 201-207 Zlotta AR, Wildschutz T, Raviv G, Peny MO, van Gansbeke D,Noel JC, Schulman CC (1997) Radiofrequency interstitial tumor ablation (RITA) is a possible new modality for treatment of renal cancer ex vivo and in vivo experience. J Endourol 11 251-258... 

RFA is a safe and minimally invasive tumor ablation therapy which rapidly reduces pain and improves quality of life in patients with bone metastases. Recent advances in different generator and applicator systems as well as in different guiding/monitor-ing technologies will overcome previous shortcomings. Particularly because of its ability to evaluate the results of the treatment immediately, RFA has the potential to be an effective option in the local treatment of bone tumors. 

LITT is a widely used technique for minimally invasive tumor ablation throughout the body with a main focus on liver metastases. Palliative treatment options for recurrent head and neck cancer are limited by the proximity of vital vascular and neural structures and the aggressive nature of these tumors. A minimally invasive treatment modality such as interventional MR-guided LITT offers a number of potential treatment benefits. First, MR imaging provides unparalleled topographic accuracy due to its excellent soft-tissue contrast and high spatial resolution. Secondly, the temperature sensitivity of the Thermo-TurboFLASH and FLASH-2D sequences can be used to monitor the temperature elevation in the tumor and surrounding normal... 

Nahum Goldberg S, Dupuy DE (2001) Image-guided radiofrequency tumor ablation challenges and opportunities, part I. J Vase Interv Radiol 12 1021-1032... 

As a result, image-guided techniques for percutaneous tumor ablation play a major role in the therapeutic management of HCC. While percutaneous ethanol injection (PEI) is a well-established technique for percutaneous treatment, several newer methods of tumor destruction have been developed and clinically tested over the past few years (Lencioni et al. 2004a). Among these methods, radiofrequency (RF) ablation constitutes the most extensively studied alternative to PEI (Galandi and Antes 2004). 

Gillams AR, Less WR (2000) Survival after percutaneous, image-guided, thermal ablation of hepatic metastases from colorectal cancer. Dis Colon Rectum 43 656-661 Goldberg SN, Girnan GD, Lukyanov AN, et al (2002) Percutaneous tumor ablation increased necrosis with combined radio-frequency ablation and intravenous liposomal doxorubicin in a rat breast tumor model. Radiology 222 797-804... 

Recently, several minimally invasive, image-guided therapies have been developed for the local treatment of primary and secondary neoplasms, in patients who are poor surgical candidates. These minimally invasive methods of therapy permit the destruction of tumor without necessitating their removal and rely on different mechanisms for tumor destruction. Radiofrequency, microwave, and laser ablation all destroy tumor by thermal injury. Cryoablation and... 

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