Tumor ablation

Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. Cancer Letters, 209, 171-176. 

Intravesical infusion of linear PEI/pDNA polyplexes was evaluated in patients with superficial bladder cancer where intravesical therapy with bacillus Calmette-Guerin had failed [6, 224]. Patients had low grade superficial bladder cancer, which expressed H19. The therapeutic pDNA contains H19 gene regulatory sequences that drive the expression of an intracellular toxin. Escalating doses of 2-20 mg plasmid per intravesical treatment were applied, with responders continuing to receive polyplexes once a month every month for 1 year. The treatment resulted in complete ablation of the marker tumor, without any new tumors in four of the 18 patients (22% overall complete response rate). Eight of the 18 patients (44%) had complete marker tumor ablation or a 50% reduction of the marker lesion. 

Harrod-Kim P (2006) Tumor ablation with photodynamic therapy introduction to mechanism and clinical applications. Journal of Vascular and Interventional Radiology 17 1441-1448. 

O Neal DP, Hirsch LR, Halas NJ, Payne JD, West J (2004) Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. Cancer Lett 209 171-176... 

Kim, R.D., Nazarey, R, Katz, E., Chari, R.S. Laparoscopic staging and tumor ablation for hepatocellular carcinoma in Child C cirrhotics evaluated for orthotopic liver transplantation. Surg. Endosc. 2004 18 39-44... 

An interesting example of a new approach currently in clinical trials is to combine radio-frequency tumor ablation with intravenous liposomal doxorubicin, which resulted in better tumor accumulation of liposomes and increased necrosis in tumors (199, 200). 

Goldberg SN et al (2002) Percutaneous tumor ablation Increased necrosis with combined radio- frequency ablation and intravenous liposomal doxorubicin in a rat breast tumor model. Radiology 222 797-804... 

Shiratori Y, Shiina S, Teratani T, Imamura M, Obi S, Sato S, et al. Interferon therapy after tumor ablation improves prognosis in patients with hepatocellular carcinoma associated with hepatitis C virus. Ann Intern Med 2003 138 299-306. 

Over 200,000 gastrointestinal malignancies are diagnosed annually in the United States, and the liver is the predominant site of metastasis in most of them. Although there have been significant advances in systemic chemotherapy, most patients will eventually succumb to their disease. As a result, much effort has been expended to develop and investigate methods of local liver tumor ablation aimed at achieving improved outcomes. 

Percutaneous tumor ablation techniques are now well established in the curative or palliative treatment of patients with primary or secondary malignant tumors of the liver. 

Robotic System for Intraoperative US-Guided Hepatic Tumor Ablation... 

Robot-assisted hepatic tumor ablation (Doctor et al. 2004) Johns Hopkins University (Baltimore, MD, USA) Phantom studies Ultrasound... 

A Step Towards Supraconservative Surgery 103 Interventional Procedures for the Locoregional Treatment of Breast Cancer 105 Percutaneous Imaging-Guided Tumor Ablation 105 Intraarterial Infusion Chemotherapy 106 References 106... 

In past decades, a variety of treatment modalities have been proposed in the battle against breast cancer. Among these therapies, minimally invasive imaging-guided tumor ablation and intraarterial chemotherapy are approaches that deserve further consideration. 

Cline HE, Hynynen K, Watkins RD, Adams WJ, Schenck JF, Ettinger RH, Freund WR, Vetro JP, Jolesz FA (1995) Focused US system for MR imaging-guided tumor ablation. Radiology 194 731-737... 

For RF ablation of HCC, patients must be Child-Pugh class A or B because in cases with end-stage liver cirrhosis (class C), treatment of tumor probably does not increase patient survival. In patients with hepatic metastases, the rationale for RF tumor ablation is based on the demonstration that in certain types of malignancies, surgical removal of hepatic tumor burden improves survival (Selzner et al. 2000 Benevento et al. 2000). 

Gazelle GS, Goldberg SN, Solbiati L, Livraghi T (2000) Tumor ablation with radio-frequency energy. Radiology 217 ... 

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