Growth suppressants

Systemic adverse effects are dose-dependent and are rare at low to medium doses however, high-dose inhaled corticosteroids have been associated with adrenal suppression, decreased bone mineral density, skin thinning, and easy bruising.3,29 Growth suppression in children may occur even with low-dose inhaled corticosteroids however, suppression appears to occur primarily in the first year of treatment and may be due to delayed growth with the potential of future catch-up growth.30... 

Growth suppression or delay is a major concern for parents of children taking stimulants. However, the evidence of this side effect is not dear. At present, growth delay appears to be transient and to resolve by midadolescence, but more data are needed to firmly resolve this issue.10 Another concern is the risk of substance abuse with stimulant use. A diagnosis of ADHD alone increases the risk of substance abuse in adolescents and adults. However, stimulant use has not been shown to further increase this risk but actually may decrease this risk, provided ADHD is treated adequately.15... 

Schaffert D, Kiss M, Rodl W, Shir A, Levitzki A, Ogris M, Wagner E (2011) Poly(I C)-mediated tumor growth suppression in EGF-receptor overexpressing tumors using EGF-polyethylene glycol-linear polyethylenimine as carrier. Pharm Res 28 731-741... 

Y. I. Kageyama, Y. Yamazaki, A. S. Afify, Y. Ogawa, T. Okada, H. Okuno, Stereoselective Hydrolysis of Xenobiotic Esters by Different Cell Lines from Rat Liver and Hepatoma and Its Application to Chiral Prodrugs for Designated Growth Suppression of Cancer Cell , Chirality 1995, 7, 297 - 304. 

Jensen, D. E., et al., BAPl a novel ubiquitin hydrolase which binds to the BRCAl RING finger and enhances BRCAl-mediated cell growth suppression. Oncogene, 1998, 16(9), 1097-112. 

Matsuzawa, S., et al., p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth suppression by BAG-1. Embo J, 1998, 17(10), 2736-47. 

Pushkareva, M., Chao, R., Bielawska, A., Merrill Jr, A.H., Crane, H.M., Lagu, B., liotta, D. and Hannun, Y.A., 1995, Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine, Biochem. 34 1885-1892. 

Strahl BD, Allis CD (2000) The language of covalent histone modifications. Nature 403 41-45 Suganuma T, Kawabata M, Ohshima T, Ikeda MA (2002) Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator. Proc Natl Acad Sci USA 99 13073-13078 Timmermann S, Lehrmann H, Polesskaya A, Harel-Bellan A (2001) Histone acetylation and disease. Cell Mol Life Sci 58 728-736... 

Adedipe, N. O., and D. P. Ormrod. Ozone-induced growth suppression in radish plants in relation to pre- and post-fumigation temperatures. Z. Pflanzenphysiol. 71 281-287, 1974. 

Guan, K., Jenkins, C., Nichols, M., Wu, X., O Keefe, C., Matera, G., and Xiong, Y. (1994). Growth suppression by pi8, a pl6Ink4/Mtsl- and Mts2-related Cdk6 inhibitor, correlates with wild-type pRb function, Genes Dev 8, 2939-2952. 

Reduction in growth velocity Closely follow the growth of adolescents taking corticosteroids, and weigh the benefits of corticosteroid therapy and asthma control against the possibility of growth suppression. 

Long-term suppression of growth Suppression of growth has been reported with long-term use in children. Interrupt treatment for patients who are not growing or gaining weight as expected. 

Goldstein DR, Cacace AM, Weinstein IB (1995) Overexpression of protein kinase C pi in the SW480 colon cancer cell line causes growth suppression. Carcinogenesis 16 1121-1126... 

Sublethal plant exposures to a number of phytotoxic air pollutants can cause the reversible suppression of one of life s most basic processes— photosynthesis. The possibility of plant growth suppression by atmospheric pollution is a concern of many people. We need to know if subnecrotic pollutant exposures that may occur in ambient air can repress photosynthesis rates sufficiently to cause significant retardation of plant growth. Some insight into the capability for short-term exposures to HF, CI2, O3, S029 NO2 and NO— applied singly and as dual pollutant mixtures— to suppress apparent photosynthesis rates of several important crop species is presented here. 

Mometasone Triamcinolone acetonide for oral corticosteroid growth suppression... 

Endocrine system Cushing s habitus, hirsutism, retardation of growth, suppression of hypothalamopituitary-adrenal axis. 

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