Growth hormone-release inhibiting

Somatostatin [38916-34-6] M 1637.9, [a]p -36 (c 0.57, 1% AcOH). A tetradecapeptide which is purified by gel filtration on Sephadex G-25, eluting with 2N AcOH, and then by liquid partition chromatography on Sepahdex G-25 using n-BuOH-AcOH-H20 (4 1 5) and has Rp= 0.4. It is a brain growth hormone releasing-inhibiting factor which has also been synthesised. [Burgus et al. Proc Natl Acad Sci USA 70 684 1973, Sorantakis and McKinley Biochem Biophys Res Commun 54 234 1973 Hartridt et al. Pharmazie 37 403 1982.]... 

Somatostatin SOM SST14 SST28 Somatotropin release inhibitory factor (SRIF) Growth hormone release-inhibiting factor... 

Somatostatin is a regulatory cyclic peptide, which has originally been described as a hypothalamic growth hormone release-inhibiting factor. It is produced throughout the central nervous system (CNS) as well as in secretoty cells of the periphery and mediates its regulatory functions on cellular processes such as neurotransmission, smooth muscle contraction, secretion and cell proliferation via a family of seven transmembrane domain G-protein-coupled receptors termed sstx 5. 

Growth Hormone Release-inhibiting Factor GSK3... 

Somatostatin Growth hormone-release inhibiting factor (8,9) (51110-01-1)... 

Somatostatin (Growth Hormone-Release-Inhibiting Hormone). 120... 

GH, growth hormone GHB, y-hydroxybutyrate GHB-R, y-hydroxybutyrate receptor GH-RIF, growth hormone-release inhibiting factor, somatostatin... 

Coy DH, Coy EJ, Arimnra A, Schally AV. Solid-phase synthesis of growth hormone-release inhibiting factor. Biochem. Biophys. Res. Commnn. 1973 54 1267-1273. 

Somatostatin, growth hormone release inhibiting hormone, occurs in other parts of the brain as well as in the hypothalamus, and also in some peripheral tissues, e.g. pancreas, stomach. In addition to the action implied by its name, it inhibits secretion of thyrotrophin, insulin, gastrin and serotonin. 

Hocart, S.J., Reddy, V., Murphy, W.A. and Coy, D.H. (1995). Three-Dimensional Quantitative Structure-Activity Relationships of Somatostatin Analogs. 1. Comparative Molecular Field Analysis of Growth Hormone Release Inhibiting Potencies. J.Med.Chem., 38,1974-1989. 

Somatostatin(growth hormone release-inhibiting hormone) is a tetradecapeptide with an intrachain disulfide bridge. Somatostatin neurons are located in the parvi-cellular neurons of the PVN, the periventricular nuclei... 

Conversely, GH secretion is suppressed by growth hormone release-inhibiting hormone (GHRIH, also called somatostatin, which has already been discussed). In addition, IGF-I, produced primarily in the liver in response to the action of GH on hepatocytes, feeds back negatively on the somatotrophs to limit GH secretion. Other physiologic factors (e.g., exercise and sleep) and many pathologic factors conuol its release (Table 43.2). 

Growth hormone release-inhibiting hormone (GHRIH) (Somatostatin)... 

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