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Growth Hormone Calcium

Somatotropin (growth hormone), calcium homeostasis, and bone development... [Pg.48]

There seems to be no metabolic control exerted on hepatic 25-hydroxylase and so all of the available cholecalciferol is converted. Hydroxylation in the kidney however is an important control point being regulated by PTH, and indirectly therefore by calcium and phosphate concentrations. Stimulation of la-hydroxylase by PTH is via a cyclic AMP (cAMP) -dependent mechanism and longer-term regulation of the activity of this enzyme is via induction mediated by other hormones such as oestrogens, cortisol and growth hormone. Typically, the plasma concentration of 1,25 dihydroxy vitamin D is in the range 20-60 ng/1, that is approximately 1000-times lower than that of its precursor. [Pg.300]

The pharmacokinetics of morphine have been studied,201-203 as has its receptor binding,204-206 and its effects on hypothermia,207 on calcium uptake by synaptosomes208 and lysed synaptosomes,209 on metabolism of catecholamine in brain,210 on levels of corticosteroids and growth hormone in plasma,211 on leuteinising hormone,212 follicle-stimulating hormone,212 and prolactin,212-215 on neuroendocrine function,216 on brain function and biochemistry,217-226 on behaviour,227-240 on the gastrointestinal tract241 and on the cardiovascular... [Pg.108]

Endocrine and metabolic Blood tests Serum concentrations of pituitary horrmones (TSH, LH, FSH, ACTH, growth hormone, prolactin, vasopressin) serum concentrations of other hormones (insulin parathyroid hormone, glucagon, calcitonin, vitamin D) and serum electrolyte concentrations (sodium, potassium, calcium, magnesium)... [Pg.170]

Hazel SJ, Gillespie CM, Moore RJ et al. (1994) Enhanced body growth in uremic rats treated with IGF-I and growth hormone in combination. Kidney Int 46 58-68 Jarusiripipat C, Chan L, Shapiro JI, Schrier RW (1992) Effect of long-acting calcium entry blocker (anipamil) on blood pressure, renal function and survival of uremic rats. J Pharmacol Exp Ther 260 243-247... [Pg.127]

Bone is a relatively dynamic organ that undergoes significant turnover that is, hone resorption and deposition it is broken down hy osteoclasts and rebuilt by osteoblasts. Besides an adequate supply of calcium, a close cooperation is required between these two types of cell. Complex signalling pathways achieve proper rates of growth and differentiation these pathways include the action of several hormones, including parathyroid hormone (PTH), vitamin D, growth hormone, steroids and calcitonin, as well as several cytokines. [Pg.185]

Space travel is associated with a decrease in blood and plasma volumes and is further associated with increases in plasma antidiuretic hormone, atrial natriuretic peptide, growth hormone, cortisol, and corticotropin concentrations. In contrast, the plasma renin activity may be decreased by as much as 50%. Plasma aldosterone may also decrease but to a lesser extent. In spite of the stress of space travel the plasma concentrations of catecholamines are usually unaffected. Plasma and urine calcium concentrations increase during... [Pg.453]

Growth hormone/insulin-like growth factors Absence during bone growth causes slow growth and short stature (dwarfism). Unknown may not be directly related to calcium and vitamin D metabolism. [Pg.877]

F8. Fraser, R., and Harrison, M., The effect of growth hormone on urine calcium excretion. Ciba Foundation CoUoq. Endocrinol. 18, 135-143 (1960). [Pg.315]

This active vitamin D metabolite (1,25 dihydroxycholecalciferol) is an important cofactor for intestinal calcium absorption, which involves calbindins (calcium binding proteins) in the intestine and kidney. Calcitriol is produced in the kidneys by the conversion of 25-hydroxycholecalciferol (calcidiol) and its formation is stimulated by a reduction of plasma calcium and/or phosphate and increased production of parathyroid hormone and prolactin (Figure 6.3). Calcitriol also inhibits the release of calcitonin and, together with PTH, increases the absorption of calcium and phosphate from the gastrointestinal tract and the kidneys. Growth hormone, glucocorticoids, estrogens, testosterone, and the thyroid hormones also influence calcium metabolism. [Pg.121]

Holl, R.W., M.O. Thomer, G.L. Mandell, J.A. Sullivan, Y.N. Sinha D.A. Leong. 1988. Spontaneous oscillations of intracellular calcium and growth hormone secretion. / Biol. Chem. 263 9682-5. [Pg.552]

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