Growth factors controlled release

A receptor-mediated gene delivery system using streptavidin and biotin-derivatized, pegylated epidermal growth factor. /. Control. Release 83 109-119. 

Kim T K, Burgess D J (2002). Pharmacokinetic characterization of 14C-vascular endothelial growth factor controlled release microspheres using a rat model. J. Pharm. Pharmacol. 54 897-905. 

Alginate microheads were prepared by crossHnking with Ca +. Immobilization of endothelial cell growth factor. Controlled release of. sulphametlioxaz.ole. Controlled release of herbicides. Pfister et al., 1986 Ko el al., 1995 Badwan el al., 1985... 

Sakiyama-Elbert, S.E. and HubbeU, J.A., Development of fibrin derivatives for controUed release of heparin-binding growth factors, /. Control. Release 65,389—402,2000a. 

Controls release of hepatic insulin-like growth factor Controls production of iodothyronines Promotes milk production... 

Figure 3.7 Schematic of stimulated nerve growth factor (NGF) release, (a) Voltage applied across the polymer in PBS solution causes the release of the biotin from the PPy surface. (b)A3V stimulation of the PPy showed an increase in theamountof NGF released from the surfaceofthe conductive poiymer. Short stimulations of 30 s did not result in as much release as long stimulations of 150 s. The asterisk indicates a statistical difference versus short stimulation, no stimulation and no biotin dopant (p <0.05) (Reprinted with permission from George, P. M., LaVan, D. A., Burdick, J. A. et al. Electrically Controlled Drug Delivery from Biotin-Doped Conductive Polypyrrole, Advanced Materials, 18, 5, 577-81. Copyright (2006) Wiley-VCH Verlag GmbH).

Yamamoto, M. et al.. Bone regeneration by transforming growth factor bl released from a biodegradable hydrogel, /. Control. Release, 64,133,2000. 

A device designed to determine the transport of an epidermal growth factor from a Pluronic gel, a Carbopol gel, and a vanishing cream base was shown capable of demonstrating formulation-dependent release kinetics [22], This device consists of a release cell which has a membrane to minimize release due to mechanical breakdown and is placed in a stirred and temperature-controlled receptor fluid. 

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