Growth cones cell adhesion molecules

Meiri, K. F., Saffell, J. L., Walsh, F. S. and Doherty, P. Neurite outgrowth stimulated by neural cell adhesion molecules requires growth-associated protein-43 (GAP-43) function and is associated with GAP-43 phosphorylation in growth cones. /. Neurosci. 18 10429-10437,1998. 

Kamiguchi H, Lemmon V 1997 Neural cell adhesion molecule LI signalling pathways and growth cone motility. J Neurosci Res 49 1—8... 

Burden-Galley SM, Pendergast M, Lemmon V (1997) The role of cell adhesion molecule LI in axonal extension, growth cone motiUty, and signal transduction. CeU Tissue Res 290 415-422... 

Forscher and Smith, 1988). In this view, any molecule on the membrane of the growth cone that takes part in a receptor-ligand interaction leading to intracellular changes of the type referred to above could be considered to be an axon guidance molecule - a definition that encompasses a far wider variety of molecules than those traditionally considered to be cell adhesion molecules. 

Letoumeau, P.C. and Shattuck, T.A. (1989) Distribution and possible interactions of actin-associated proteins and cell-adhesion molecules of nerve growth cones. Development 105 505-519. 

While the identity of cell adhesion receptor molecules remains unclear, there is considerable evidence that the intracellular signal transduction pathways which link reception of an extracellular signal with changes in growth cone behaviour involve changes in the level of intracellular Ca + ([Ca +li). Again, invertebrate systems have made a significant contribution in this area. 

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