Group-specific component

An example of the use of polyacrylamide gels in an ief system in combination with immun obi otting is given in Reference 40 where this method is used to detect low quantities of group specific component (GC) subtypes. Another example of polyacrylamide in combination with ief is given in Reference 41 where the technique is used as a screening tool for inheritance of a certain polymorphic protein. 

Group-specific component protein This substance (= a2-globu-lin) is synthesized in the liver and binds actin. GCP is released upon hepatocyte decay its pronounced reduction in the serum results from the decrease in synthesis in acute liver failure. 

GC protein (group-specific component) is an a2-globulin which is synthesized in the liver and which binds actin released due to hepatocyte decay. Decreased GC-protein values in the plasma are thus attributable both to its reduced synthesis in acute liver failure and its increased binding to actin as a result of hepatocellular disintegration. A value of <34 pg/ml was associated with a lethal outcome in some 70% of cases. 

Conversion of provitamin D (ergosterol or 7-dehydrochoIesteroi) to vitamin D in the skin and its transport in the blood complexed with vitamin D-binding protein (also known as transcalciferin, Gc-protein, and group-specific component). 

Group-specific component is a serum protein involved with Vitamin-D transport ( ). By conventional electrophoresis three common phenotypes -1, 2-1, and 2- can be observed. 

Many teichoic acids are serologically active and often constitute the group-specific components of bacteria. By the use of specific antibodies, it was established that B. subtilis W-23 contains two teichoic acids in the cell wall both are ribitol teichoic acids, but... 

Cleve, H., Beam, A. G. 1961. Inherited variations in human serum proteins Studies on the group-specific component. Ann N Y Acad Sci, 94 218-24. 

Constans, J., Viau, M. 1977. Group-specific component Evidence for two subtypes of the Gel gene. Science, 198 1070-1. 

Daiger, S. R, Schanfield, M. S., Cavalli-Sforza, L. L. 1975. Group-specific component (Gc) proteins bind vitamin D and 25-hydroxy vitamin D. Proc Natl Acad Sci USA, 72 2076-80. 

Hirai, M., Suzuki, S., Hinokio, Y, et al. 1998. Group specific component protein genotype is associated with NIDDM in Japan. Diabetologia, 41 742-3. 

Yamamoto, N., Homma, S. 1991. Vitamin D3 binding protein (group-specific component) is a precursor for the macrophage-activating signal factor from lysophosphatidylcholine-treated lymphocytes. Proc Natl Acad Sci USA, 88 8539-43. 

Bearn, A. G. Genetic variations in the serum proteins studies on transferrin and the group specific components. 2nd Int. Cong. Congenital malformations. New York 1963, p. 125, Int. Med. Congr. Ltd, New York 1964. 

Group-specific component (Gc) Vitamin-D-binding globulin (VDBG)... 

Brissenden, J. E., and Cox, D. W., 1978, Electrophoretic and quantitative assessment of vitamin D-binding protein (group-specific component) in inherited rickets, /. Lab. Clin. Med. 91 455. 

Svasti, J., and Bowman, B. H., 1978, Human group-specific component, J. Biol. Chem. 253 4188. 

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