Binding globulin

This structure encoding method has been applied both for the classification of a data set comprising 31 corticosteroids, for which affinity data were available in the literature, binding to the corticosteroid-binding globulin (CBG) receptor, and for the simulation of infrared spectra [28, 29). 

Thyroxine (3, 5, 3,5-L-teraiodothyronine, T4) is a thyroid hormone, which is transformed in peripheral tissues by the enzyme 5 -monodeiodinase to triiodothyronine. T4 is 3-8 times less active than triiodothyronine. T4 circulates in plasma bound to plasma proteins (T4-binding globulin, T4-binding prealbumin and albumin). It is effective in its free non-protein-bound form, which accounts for less than 1%. Its half-life is about 190 h. 

DHEA Dehydroepiandrosterone SHBG Sex hormone-binding globulin... 

Thyroid Hormones Are Transported by Thyroid-Binding Globulin... 

Ceruloplasmin (contains Cu + albumin probably more important in physiologic transport of Cu T Corticosteroid-binding globulin (trans-cortin) (binds cortisol)... 

Hemopexin (binds heme) Retinol-binding protein (binds retinol) Sex hormone-binding globulin (binds testosterone, estradiol) Thyroid-binding globulin (binds T4, T3) Transferrin (transport iron)... 

LOUKOVAARA M, CARSON M, PALOTIE A, ADLERCREUTZ H (1995) Regulation of sex hormone-binding globulin production by isoflavonoids and patterns of isoflavonoid conjugation in HepG2 cell cultures. Steroids. 60 656-61. 

MOUSAVi Y, ADLERCREUTZ H (1993) Genisteiu is an effective stimulator of sex hormone-binding globulin production in hepatocarcinoma hinnan hver cancer cells and suppresses proliferation of these cells in culture. Steroids. 58 301-4. 

PINO A M, VALLADARES L E, PALMA M A, MANCILLA A M, YANEZ M, ALBALA C (2000) Dietary isoflavones affect sex hormone-binding globulin levels in postmenopausal women. J Clin Endocrinol Metab. 85 2797-800. 

S-Adenosylmethionine carboxylase Sex-hormone binding globulin CYP 2D6 Falcipain 2 and 3 SARS CoV Chkl kinase Heme oxygenase... 

As noted above, many of the AEDs induce hepatic microsomal enzyme systems and thus reduce the effectiveness of hormonal contraceptives. Women taking AEDs that may reduce the effectiveness of hormonal contraceptives should be encouraged to also use other forms of birth control. Due to induction or inhibition of sex hormone metabolism and changes in binding of hormones to sex hormone binding globulin, some AEDs may reduce fertility. For example, valproate has been associated with a drug-induced polycystic ovarian syndrome. Women who experience difficulties with fertility should seek the advice of health care professionals with expertise in fertility. 

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