Granulomatous disease inflammation

Sihcosis, due to the inhalation of crystalline tetrahedral (quartz, tridymite, cristobalite) - but not octahedral (stishovite) - silicon dioxide, is characterised by granulomatous inflammation of the lung. As in various granulomatous diseases, such as other pneumoconioses, sarcoidosis, and tuberculosis, sihcosis is characterised by an early mononuclear cell infiltration of the lung parenchyma followed by resident cell activation and proliferation (Becklake 1994). 

The diagnosis of specific sarcoidosis skin lesions usually requires a confirmatory biopsy. On occasion, a clinical diagnosis of skin sarcoidosis may be made if the lesions are typical (e.g., lupus pernio or lesions present on scar tissue). Sarcoidosis is not the only cause of granulomatous inflammation of the skin, and other potential causes must be carefully excluded. Usually the diagnosis of skin sarcoidosis is not secure without evidence of extracutaneous granulomatous disease. 

Hypersensitivity Pneumonitis a group of respiratory diseases that cause inflammation of the lung (specifically granulomatous cells). Most forms of... 

Because Treponema pallidum is sensitive to penicillin G, this antibiotic is the drug of choice for treatment of syphilis and syphilitic eye disease (see Table 11-1). Syphilitic eye disease can include interstitial keratitis (stromal inflammation and vascularization), episcleritis, scleritis, nongranulomatous or granulomatous iritis, iris papules (collections of dilated capillaries in the iris), chorioretinitis, papillitis, retinal vasculitis, and exudative retinal detachment. Probenecid can be added to procaine penicillin to decrease excretion of the penicillin by the kidneys, thus causing an increase in penicillin plasma levels. Penicillins are not used for the treatment of minor ocular infections such as blepharitis and conjimctivitis... 

Tuberculosis can involve any region of the CNS and its coverings. The disease usually causes granulomatous inflammation with or without caseating necrosis, meningitis, or arteritis. The extensive time required to grow mycobacteria invites preliminary testing with IHC, PCR assay, or acid-fast stains. ... 

COPE with Cytokines. 2006. Available at http //www.copewithcytokines.de/. Kunitake R, Kuwano K, Miyazaki H, et al. Apoptosis in the course of granulomatous inflammation in pulmonary sarcoidosis. Eur Respir J 1999 13(6) 1329-1337. Agostini C, Zambello R, Sancetta R, et al. Expression of tumor necrosis factor-receptor superfamily members by lung T lymphocytes in interstitial lung diseases. Am J Respir Crit Care Med 1996 153 1359-1367. 

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