Keratitis interstitial

The spirochetes, which have a special morphology consisting of flexible spirals, include Treponema pallidum, which can cause syphilis. Possible syphilitic eye disease findings include interstitial keratitis, uveitis, pigmentary retinopathy, vitritis, retinal vascular sheathing, and papillitis. 

Because Treponema pallidum is sensitive to penicillin G, this antibiotic is the drug of choice for treatment of syphilis and syphilitic eye disease (see Table 11-1). Syphilitic eye disease can include interstitial keratitis (stromal inflammation and vascularization), episcleritis, scleritis, nongranulomatous or granulomatous iritis, iris papules (collections of dilated capillaries in the iris), chorioretinitis, papillitis, retinal vasculitis, and exudative retinal detachment. Probenecid can be added to procaine penicillin to decrease excretion of the penicillin by the kidneys, thus causing an increase in penicillin plasma levels. Penicillins are not used for the treatment of minor ocular infections such as blepharitis and conjimctivitis... 

Immune reaction after keratoplasty Herpes zoster keratitis Disciform keratitis Marginal corneal infiltrates Superficial punctate keratitis Chemical burns Acne rosacea keratitis Interstitial keratitis Uvea... 

Band keratopathy was first described in 1848 and is a chronic degenerative condition characterized by the deposition of calcium carbonate salts in the superficial corneal layers, most frequently in the interpalpebral area. Although there are many reported cases of idiopathic band keratopathy, some of which seem to have a hereditary component, the most common causes are associated with chronic ocular inflammation and systemic conditions resulting in altered calcium metabolism. Band keratopathy is typically seen in eyes with chronic uveitis, severe superficial keratitis, corneal ulcers, chemical burns, interstitial keratitis (IK), trachoma, phthisis bulbi, and prolonged glaucoma. The chronic anterior uveitis of juvenile idiopathic arthritis is frequently associated with band keratopathy, with one study reporting its development in 66% of patients with juvenile idiopathic arthritis. 

From Knox CM, Holsclaw DS. Interstitial keratitis. Int Ophthalmol Chn 1998 38 183-195. 

Figure 26-40 Inactive interstitial keratitis in a patient with congenital syphiUs.The presentation was bilateral. (Courtesy of Dr. Tammy Than.)...

Goegebuer A, Ajay L, Claerhout 1, et al. Resmts of penetrating keratoplasty in syphihtic interstitial keratitis. BuU Coc Beige Ophthalmol 2003 290 35-39... 

Orsom JG, Zavota L, Manzotti F, et al. Syphilitic interstitial keratitis treatment with immunosuppressive drug combination therapy. Cornea 2004 23 530-532. 

Zamir E, Read RW, Affeldt JC, Ramaswamy D, Rao NA. Gold induced interstitial keratitis. Br J Ophthalmol 2001 85(ll) 1386-7. 

The evidence has been examined carefully, and it is considered that no case can at present be made for the use of tocopherol in the following conditions in spite of the repeated claims on uncontrolled trials menopausal syndrome, senile vaginitis and pruritus, male infertility, muscular dystrophy, Dupuytren s contracture, fibrositis, Peyronie s disease, interstitial keratitis, angina pectoris, granuloma annulare, lupus erythematosus. 

Sensory systems Eyes Interstitial keratitis has been reported after varicella immunization [46 ]. 

Nagpal A, Vora R, Margolis TP, Acharya NR. Interstitial keratitis following varicella immunization. Arch Ophthalmol 2009 127 222-3. 

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