Goitrogen

Thiocyanate ion, SCN , inhibits formation of thyroid hormones by inhibiting the iodination of tyrosine residues in thyroglobufin by thyroid peroxidase. This ion is also responsible for the goitrogenic effect of cassava (manioc, tapioca). Cyanide, CN , is liberated by hydrolysis from the cyanogenic glucoside finamarin it contains, which in turn is biodetoxified to SCN. [Pg.52]

Aromatic Amines and Phenols. The discovery that sulfaguanidine [57-67-0] was goitrogenic to rats was serendipitous. Many related compounds were then examined, and the aniline moiety was usually present (2,6). Such compounds, as well as resorcinol-like phenols, may act as goitrogens by inhibiting thyroid peroxidases. These are not used clinically. [Pg.53]

P. 1. anger and M. A. Greer, Antithyroid Substances and Naturally Occurring Goitrogens, S. Karger, Basel, Switzerland, 1977. [Pg.54]

DOERGE D R and SHEEHAN D M (2002) Goitrogenic and estrogenic activity of soy isoflavones. Environ Health Perspect. 110 (Suppl 3) 349-53. [Pg.213]

The vast majority of hypothyroid patients have thyroid gland failure (primary hypothyroidism). The causes include chronic autoimmune thyroiditis (Hashimoto s disease), iatrogenic hypothyroidism, iodine deficiency, enzyme defects, thyroid hypoplasia, and goitrogens. [Pg.247]

Delange F, Ermans AM. 1971. Role of a dietary goitrogen in the etiology of endemic goiter on Idjwi Island. Am J Clin Nutr 24 1354-1360. [Pg.244]

Thilly CH, Swennen B, Bourdoux P, et al. 1993. The epidemiology of iodine-deficiency disorders in relation to goitrogenic factors and thyroid-stimulating-hormone regulation. Am J Clin Nutr 57(2 Suppl) 267S-270S. [Pg.269]

Estrogenic Glycosides (Isoflavones, Coumestans) Coumarin Glycosides Goitrogenic Glycosides Other Glycosides... [Pg.19]

Keywords Goitrogens, Thyroid follicle, Thyroid gland, Thyroid gland function dismptor, Thyroid hormone, Zebrafish... [Pg.415]

Gaitan E (1990) Goitrogens in food and water. Annu Rev Nutr 10 21-39... [Pg.430]

Gaitan E, Cooksey RC, Legan J, Cruse JM, Lindsay RH, Hill J (1993) Antithyroid and goitrogenic effects of coal-water extracts from iodine-sufficient goiter areas. Thyroid 3 49-53... [Pg.431]

The sulfonamides are chemically similar to some goitrogens, diuretics... [Pg.1911]

III.b.1.1. Anion inhibitors. Perchlorate, periodate, pertechnetate and thiocyanate (a naturally occurring goitrogen) are classified as iodide pump inhibitors, antagonizing iodide transport through competitive inhibition. This effect can be overcome by large dose of iodides. Perchlorate is used to block reuptake of iodide in cases of amiodarone induced hyperthyroidism and for the perchlorate discharge test . [Pg.759]

Goitrogenic activity. Fresh root, in the ration of rats at a dose of 9 g/day for 26 days, was active k... [Pg.208]

Goitrogenic. Producing an enlargement of the thyroid gland, causing a swelling in the front part of the neck. [Pg.569]

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