Goitrogenic activity

Goitrogenic activity. Fresh root, in the ration of rats at a dose of 9 g/day for 26 days, was active k... 

McGinty DA, Bywater WG (1945) Antithyroid studies. I. The goitrogenic activity of some thioureas, pyrimidines and miscellaneous compounds. J Pharmacol Exp Ther 84 342-357... 

The goitrogenic activity of some imidazoles and benzimidazoles. J. Pharmacol. Exp. Therap. 85, 14 (1945). 

A certain measure of control of the goitrogenic activity of meals is achieved by manipulating the pretreatment of the seed before extraction so as to ensure the earliest possible destruction of myrosinase. Such control is only partial, since bacterial thioglucosidases produced in the gut may hydrolyse residual glucosinolate in the meal. 

It is doubtful if the goitrogenic activity of all these foods is due to the same chemical compound or compounds or to the same mechanism within the animal body. Astwood and his associates have wholly or predominantly accounted for the antithyroid activity of Brassica seeds by the presence in these seeds, in a combined inactive form, of a compound which they have isolated and characterized as L-5-vinyl-2-thiooxazolidone (Fig. 6) the antithyroid compound of the cabbage family. 

DOERGE D R and SHEEHAN D M (2002) Goitrogenic and estrogenic activity of soy isoflavones. Environ Health Perspect. 110 (Suppl 3) 349-53. 

Reduction of thyroid activity and hormone effects can be accomplished by agents that interfere with the production of thyroid hormones, by agents that modify the tissue response to thyroid hormones, or by glandular destruction with radiation or surgery. Goitrogens are agents that suppress secretion of T3 and T4 to subnormal levels and thereby increase TSH, which in... 

Unlike the phytoestrogens mentioned earlier, flavones do not possess estrogenic activity. However, the flavones apigenin and luteolin act as potent inhibitors of aromatase and 17P-hydroxy-steroid oxidoreductase, enzymes involved in estrogen metabolism. Studies have also demonstrated these flavones and several glycosylflavones are potent goitrogens, particularly in association with millet consumption. 

The study of environmental goitrogenic factors other than iodine deficiency, in which IDD persists in spite of in active iodization program, is very important. Based on these observations, the recommended iodine level has to be modified to meet the adequate need and successful operation of the program. 

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