Thyroid diseases goitrogens

However, despite the decrease in the overall goiter rate in India, the prevalence of goiter, albeit at a lower rate, continues. This partial persistence of goiter in the country and its possible causes have been discussed elsewhere in this book. These may include incomplete correction of iodine deficiency, ingestion of goitrogens, or the presence of autoimmune thyroid disease. 

Results from several studies have raised speculations on the effect of isoflavones on thyroid function. Goitrogenic effects in infants fed soy-based IF were first reported in the 1960s due to increased loss of thyroxine from the gut and inhibition of thyroid peroxidase in the absence of iodine, a key enzyme in the production of thyroid hormone (Divi et al. 1997). The subsequent replacement of soy flour with SPI and supplementation of IF with iodine overcame the goitrogenic effects of soy-based IF (Merritt and Jenks 2004), and there are now no coneems regarding th Toid disease. Review of the literature suggests that there is little evidenee that thyroid function would be adversely affected by SF or SI supplementation in euthyroid, iodine-replete individuals (Messina... 

The vast majority of hypothyroid patients have thyroid gland failure (primary hypothyroidism). The causes include chronic autoimmune thyroiditis (Hashimoto s disease), iatrogenic hypothyroidism, iodine deficiency, enzyme defects, thyroid hypoplasia, and goitrogens. 

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