Glycoproteins oligosaccharides

Among structurally diverse glycoprotein oligosaccharides, those containing repeating N-acetyl-lactosamine structures attract much attention in connection with various biological events, most notably as onco-differentiation markers. 

Weiskopf, A.S. Vouros, P. Harvey, D.J. ESI-Ion Trap-MS for Stractural Analysis of Complex iV-Linked Glycoprotein Oligosaccharides. Anal. Chem. 1998, 70, 4441-4447. 

Cell surface glycoproteins/ oligosaccharides Developmental signals Extracellular matrix components Growth factors Hormones... 

In many glycoproteins oligosaccharides are linked through N-acetylglucosamine to the side chain of... 

Cummings, R. D., Merkle, R. A., and Stults, N. L. (1989). Separation and Analysis of Glycoprotein Oligosaccharides. Methods Cell Biol 32 141. 

Hettkamp H, Bause E, Legler G. Inhibition by nojir-imycin and 1-deoxynojirimycin of microsomal glucosidases from calf fiver acting on the glycoprotein oligosaccharides Glci-3Man9GlcNAc2. Biosci. Rep. 1982 2(11) 899—906. 

Ogawa and coworkers have also extensively described synthetic studies on glycoprotein oligosaccharides and mannose-containing glycosphingolipids using similar reactions [26,27, 28,29] (O Scheme 9). For instance, the reaction of 14 with disaccharide 15 afforded 16 (o = 1.1 1), which was used as the key intermediate in their first chemical synthesis of a sialic acid-containing complex-type undecasaccharide [30]. 

N.G. Karlsson, N.L. Wilson, H.-J. Wirth, P. Dawes, Negative ion GCC nano-LC-MS increases sensitivity for glycoprotein oligosaccharide analysis. Rapid Commun. Mass Spectrom., 18 (2004)2282. 

A. S. Mehta, E. Saile, W. Zhong, T. Buskas, R. Carlson, E. Kannenberg, Y. Reed, C. P. Quinn, and G.-J. Boons, Synthesis and antigenic analysis of the BclA glycoprotein oligosaccharide from the Bacillus anthracis exosporium, Chem. Eur. /., 12 (2006) 9136-9149. 

Anti-I and -i antibodies as immunosequencing reagents for glycoprotein oligosaccharides... 

W. Chai, M. S. Stoll, G. C. Cashmore, and A. M. Lawson, Specificity of mild periodate oxidation of oligosaccharide-alditols relevance to the analysis of the core-branching pattern of O-linked glycoprotein oligosaccharides, Carbohydr. Res., 239 (1993) 107-115. 

Quinternary structure (5° structure) refers to the association of one class of biomacromolecule with another class of biomacromolecule to form complexes of cellular components such as histone (DNA-protein), ribosome (RNA-protein) and glycoprotein (oligosaccharide-protein). 

A. S. Weiskopf, P. Vouros, and D. J. Harvey, Electrospray ionization-ion trap mass spectrometry for structural analysis of complex N-linked glycoprotein oligosaccharides, Anal. Chem. 70, 4441-4447 (1998). 

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