Glycoproteins oligosaccharide determinants

The final chapter, by Hounsell (London), also relates to an important aspect of glycoprotein structure, namely the structures and shapes, as determined by physicochemical methods, of oligosaccharide determinants of glycoproteins that are antigens and targets for binding of adhesion molecules. 

Cannon, K., and Helenius, A. (1999). Trimming and readdition of glucose to N-linked oligosaccharides determines calnexin association of a substrate glycoprotein in living cells. J. Biol. Chem. 274, 7537-7544. 

Hounsell, E.F. (1994) Physicochemical analysis of oligosaccharide determinants of glycoproteins. Adv. Carbohydr. Chem. Biochem., 50, 311-350. 

The precise chemical nature of some of the ligands involved in selectin-ligand interactions has been determined. All three selectins bind sialylated and fucosy-lated oligosaccharides, and in particular all three bind sialyl-Lewis (Figure 47-12), a structure present on both glycoproteins and glycolipids. Whether this compound is the actual ligand involved in vivo is not estab-... 

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