Synthesis of Polysaccharides, Oligosaccharides, Glycoproteins, Glycopeptides, and Glycolipids

1 Synthesis of Polysaccharides, Oligosaccharides, Glycoproteins, Glycopeptides, and Glycolipids 

Recent advances in the synthesis of disaccharides, glycosphingolipids, and oligosaccharides have been described. Progress in synthesizing human blood group antigenic determinants has been reviewed.  

Polysaccharides. — Poly(urea-urethane)s containing 2-acetamido-2-deoxy-D-glucosyl residues in the main chain have been prepared by direct addition polymerization of 2-acetamido-2-deoxy-D-glucose and di-isocyanates. The polymers were soluble in polar solvents and exhibited good reactivity toward acetylation and very high water absorption. 

Several copolymers of styrene and 2,3 4,5-di-0-isopropylidene-l-vinylbenzyl-/3-D-fructopyranose have been prepared by free-radical initiation. The specific rotation of the copolymers was linearly related to their molar compositions, which also affected the glass transition temperatures. 

Novel polymers which show a high degree of water absorption have been synthesized by direct addition polymerization of o ,a-trehalose with di-isocyanates.  

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