Glutathione reductase activity

K8. Kerppola, W., Nikkila, E. A., and Pitkanen, E., Serum TPN linked enzymes glucose-6-phosphate dehydrogenase, isocitric dehydrogenase and glutathione reductase activities in health and various disease states. Acta Med. Scand. 164, 357-305 (1959). 

Besides these inconsistent findings in peripheral tissue, analysis of patient s postmortem brain indicates lower GPX and glutathione reductase activities in striatum (Yao et al., 2006), elevated Mn-SOD activity (Loven et al., 1996) and elevated Mn-SOD protein levels in cortex (Michel et al., 2004). On the other hand, Cu- and Zn-SOD levels were reported not to be altered (Loven et al., 1996), whereas their enzymatic activity were... 

Kami, L., Moss, S.J., and Tel-Or, E. (1984) Glutathione reductase activity in heterocysts and vegetative cells of cyanobacterium Nostoc muscorum, Arch. Microbiol. 140, 215-217. 

In pregnant women, there is a progressive increase in the erythrocyte glutathione reductase activation coefficient (an index of functional riboflavin nutritional status Section 7.5.2), which resolves on parturition despite the daily secretion of 200 to 400 /rg (0.5 to 1 /rmol) of riboflavin into milk. This suggests that the estrogen-induced riboflavin binding protein can sequester the vitamin for fetal uptake at the expense of causing functional deficiency in the mother. 

The impairment of glutathione reductase activity may result in lower availability of glutathione in erythrocytes and hence a more oxidizing environment, which is hostile to the parasites. 

Dubick MA, Gretz D, and Majumdar AP (1995) Overt vitamin B-6 deficiency affects rat pancreatic digestive enzyme and glutathione reductase activities./oMrttfl/of Nutrition 125, 20-5. 

Clements JE and Anderson BB (1980) Glutathione reductase activity and pyiidoxine (pyridoxamine) phosphate oxidase activity in the red cell. Biochimica etBiophysica Acta G32,159-63. 

In 15 patients who had a serious adverse reaction to valproate (including behavioral changes and emesis in six, raised aspartate transaminase in three, raised aspartate transaminase and pancreatitis in one, thombocytopenia in two, and unexpected death in two), erythrocyte glutathione peroxidase activity and plasma selenium and zinc concentrations were significantly reduced, whereas erythrocyte glutathione reductase activity was significantly raised... 

Moreover, intracellular accumulation and cytochrome P450 catalyzed bioactivation of p-lactams such as cephaloridine overwhelms of the GSH redox cycle by inhibiting glutathione reductase activity [35, 56], depletion of GSH and accumulation of GSSG [35, 42, 49,56]. Most of GSSG formed is subsequently reduced by glutathione reductase and GSH is regenerated with concomitant oxidation (consumption) of NADPH to NADP+ [104]. 

Urinary thiamine excretion Erythrocyte thiamine concentration Erythrocyte glutathione reductase activity Erythrocyte flavin... 

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