Plasma glutathione reductase activity

In 15 patients who had a serious adverse reaction to valproate (including behavioral changes and emesis in six, raised aspartate transaminase in three, raised aspartate transaminase and pancreatitis in one, thombocytopenia in two, and unexpected death in two), erythrocyte glutathione peroxidase activity and plasma selenium and zinc concentrations were significantly reduced, whereas erythrocyte glutathione reductase activity was significantly raised... 

B tflibollavin) Rarely single rteTiciency Plasma levels or RBC glutathione reductase activation... 

Cocoa powder exerted anticancer properties in in vivo studies. Amin et al. [50] indicated that cocoa liquor extract lowered the activity of tumor marker enzymes (alkaline phosphatase, gamma-glutamyl transpeptidase, glutathione-S-transferase, and glutathione reductase activities) in plasma and/or liver of hepatocarcinogenic male Sprague-Dawley rats, which were induced with diethylnitrosamine and 2-acetylaminofluorene. 

Riboflavin status is assessed by (1) determination of urine riboflavin excretion, (2) a functional assay using the activation coefficient of stimulation of the enzyme glutathione reductase by FAD, or (3) direct measurement of riboflavin or its metabolites in plasma or erythrocytes. The advantages and disadvantages of functional or direct methods have been discussed in the section on thiamine. 

The reference interval for eiythrocyte riboflavin using a fluorometric method is 10 to 50jig/dL (266 to 1330nmol/L). The reference interval for serum or plasma levels of riboflavin is 4 to 24 Lig/dL (106 to 638 nmol/L). Guidance reference intervals for the activation coefficient of erythrocyte glutathione reductase by FAD are 1.20 (adequacy), 1.21 to 1.40 (marginal deficiency), and 1.41 and above (deficiency)... 

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