Glutathione peroxidase, erythrocyte

THE PENTOSE PHOSPHATE PATHWAY GLUTATHIONE PEROXIDASE PROTECT ERYTHROCYTES AGAINST HEMOLYSIS... 

Figure 20-3. Role of the pentose phosphate pathway in the glutathione peroxidase reaction of erythrocytes. (G-S-S-G, oxidized glutathione G-SH, reduced glutathione Se, selenium cofactor.)...

In erythrocytes, the pathway has a major function in preventing hemolysis by providing NADPH to maintain glutathione in the reduced state as the substrate for glutathione peroxidase. 

Glutathione-peroxidase (GSH-Pxase) is an enzyme found in erythroqrtes and other tissues that has an essential selenocysteine residue involved in the catalytic decomposition of reactive oxygen species. In the erythrocyte, hydrogen peroxide is the principle reactive oxygen species available. 

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Cohen, G. and Hochstein, P. (1963). Glutathione peroxidase the primary agent for the elimination of hydro n peroxide in erythrocytes. Biochemistry 2, 1420-1428. 

Higuchi, M., Cartier, L.J., Chen, M. and HoUoszy, J.O. (1985). Superoxide dismutase and catalase in skeletal muscle adaptive response to exercise. J. Gerontol. 40, 281-286. Hunter, M.I.S., Brzeski, M.S. and de Vane, P.J. (1981). Superoxide dismutase, glutathione peroxidase and thiobarbi-turic acid-reactive compounds in erythrocytes in Duchenne muscular dystrophy. Clin. Chim. Acta 115, 93-98. 

Bibi, H., Schlesinger, M., Tabachnik, E., Schwartz, Y., Iscovitz, H. and laina, A. (1988). Erythrocyte glutathione peroxidase activity in asthmatic children. Ann. Allergy 61, 339-340. 

P9. Perona, G., Guidi, G. C., Piga, A., Cellerino, R., Milani, G., Colautti, P., Moschini, G., and Stievano, B. M Neonatal erythrocyte glutathione peroxidase deficiency as a consequence of selenium imbalance during pregnancy. Br. J. Haematol. 42,567-574 (1979). 

Other examples of possible damaging effects of radio frequency MFs on humans are the MF effects on cellular phones. Moustafa et al. [216] suggested that acute exposure to the MFs of commercially available cellular phones for 1, 2, or 4 h significantly increased plasma lipid peroxidation and decreased the activities of SOD and glutathione peroxidase in erythrocytes. 

C. carpio 10 during exposure for 96 h, significant alterations were recorded in lipid peroxidation rate, hemoglobin concentration, and erythrocyte antioxidant enzymes, that is, catalase, superoxide dismutase, and glutathione peroxidase activities 20... 

Plagia D, Valentine W (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Chn Med 70 158-169... 

Swanson AB, Wagner PA, Ganther HE, et al. 1974. Antagonistic effects of silver and tri-o-cresyl phosphate on selenium and glutathione peroxidase in rat liver and erythrocytes [Abstract], Fed Proc... 

Washburn, M.P., and Wells, W.W. 1999. Identification of the dehydroascorbic acid reductase and thioltransferase (glutaredoxin) activities of bovine erythrocyte glutathione peroxidase. Biochem. Biophys. Res. Commun. 257 567-571. 

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