Glutamate-mediated cell death

Hermann G. E., Rogers R. C., Bresnahan J. C., and Beattie M. S. (2001). Tumor necrosis factor-a induces cFOS and strongly potentiates glutamate-mediated cell death in the rat spinal cord. Neurobiol. Dis. 8 590-599. 

RNA interference-mediated silencing of GM3 synthase protects HT22 cells from glutamate-mediated cell death. Collective evidence suggests that GM1 and GM3 gangliosides act very differently in brain tissue and more studies are required on the molecular mechanism of action of various gangliosides in brain tissue. 

In cerebellar granule cells, glutamate-triggered, Ca -mediated cell death is independent of endogenous NO production (Lafon-Cazal et al. 1993). A rather inverted mechanism has been demonstrated in these neurones exposure to NO donors leads to stimulation of N-methyl-D-aspartate receptors, probably because NO-related species stimulate the release of endogenous agonists (Leist et al. 1997). This sort of stimulation eventually causes apoptosis (Bonfoco et al. 1996). 

Jung H, Toth PT, White PA, Miller RJ (2008) Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J Neurochem 104 254-263 Kahn L, Alonso G, Normand E, Manzoni OJ (2005) Repeated morphine treatment alters polysia-lylated neural cell adhesion molecule, glutamate decarboxylase-67 expression and ceU proliferation in the adult rat hippocampus. Em J Nemosci 21 493-500 Kaul M, Ma Q, Medders KE, Desai MK, Lipton SA (2007) HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death Differ (2) 296-305... 

Dale, L. B., Bhattacharya, M., Anborgh, P. H., Murdoch, B., Bhatia, M., Nakanishi, S., and Ferguson, S. S. (2000) G protein-coupled receptor kinase-mediated desensitization of metabotropic glutamate receptor 1A protects against cell death. J. Biol. Chem. 275, 38213-38220. 

Glutamate Receptors and Glutamate-Mediated Neural Cell Death... 

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