Glucose responsive properties

Figure 4. Apparatus for in vitro measurement of dynamic response properties of the subcutaneous type glucose sensor...

Glucose sensors II and HI were prepared from the semipermeable membrane of PMSP, poly(1-trimethylsilyl-l-propyne), which has 4 times the oxygen permeability compared with that of FEP membrane. The response properties of sensor H, using a PMSP membrane with 25 Um diameter pinhole, were almost similer to that of the sensor I, so that their calibration curves were not presented in this paper. 

In vivo tests. The response properties of the glucose sensors I to IV are summarized in Table 1. The sensor HI and W have more desirable responses than the sensor I and H as a glucose sensor for the artificial pancreas. In the present paper, however, the results of in vivo tests obtained by using the sensor I will be demonstrated in the later section. 

Ram et al. reported electrochemical properties of GOD assembled with a conductive polypyrrole through LbL techniques [191]. The results obtained provided information, with respect to the electron transfer processes, on the spatial arrangement of GOD molecules on the polypyrrole surfaces, which might give crucial and important insights for construction of glucose-responsive biosensors. Wollenberger... 

As biomolecule-responsive hydrogels that undergo changes in volume by the changes in physicochemical properties of polymer backbone, there are glucose-responsive hydrogels for a potential autonomous treatment of insulin-dependent diabetes mellitus (IDDM). Insulin is a hormone secreted from the Langerhans islets of the pancreas... 

Wu Q, Wang L, Yu H, Wang J, Chen Z (2011) Organization of glucose-responsive systems and their properties. Chem Rev 111(12) 7855-7875... 

CNTs offer an exciting possibility for developing ultrasensitive electrochemical biosensors because of their unique electrical properties and biocompatible nanostructures. Luong et al. have fabricated a glucose biosensor based on the immobilization of GOx on CNTs solubilized in 3-aminopropyltriethoxysilane (APTES). The as-prepared CNT-based biosensor using a carbon fiber has achieved a picoamperometric response current with the response time of less than 5 s and a detection limit of 5-10 pM [109], When Nation is used to solubilize CNTs and combine with platinum nanoparticles, it displays strong interactions with Pt nanoparticles to form a network that connects Pt nanoparticles to the electrode surface. The Pt-CNT nanohybrid-based glucose biosensor... 

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