Glucose-responsive system

Glucose-Responsive Systems Based on Boronic Acid-Diol Complexation... 

Wu Q, Wang L, Yu H, Wang J, Chen Z (2011) Organization of glucose-responsive systems and their properties. Chem Rev 111(12) 7855-7875... 

The glucocorticoids influence or regulate functions such as the immune response system, the regulation of glucose, fat and protein metabolism, and control of the anti-inflammatory response. Table 50-1 describes the activity of the glucocorticoids within the body. 

Fig. 7. Systemic (a) human insulin concentration and (b) glucose response following infusion of human insulin from external pump, 5 months postimplantation (Dziubla et ai, 2002).

Major developments have been reported in the utilization of environmentally responsive hydrogels as glucose-sensitive systems that... 

Kitano, S., Koyama, Y., Kataoka, K., et al. A novel drug delivery system utilizing a glucose responsive polymer complex between poly (vinyl alcohol) and poly( V-vinyl-2-pyrrolidone) with a phenylboronic acid moiety. J. Contr. Rel. 19 161—170, 1992. 

The results shown in Figures 7 and 9 also indicate that the sensors based on the poly(ethylene oxide) and siloxane-ethylene oxide branch polymer systems can operate efficiently at relatively low applied potentials. In fact, the sensors containing these polymers show steady-state glucose responses at a potential of +100 mV (vs. SCE) which are similar to the response of the best poly(siloxane)-based sensor at +300 mV. This is an important consideration because lower operating potentials are often advantageous in real measurements, where easily oxidizable interfering species are usually present. 

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