Glucose Doxorubicin

Gao, J.-P. et al. (1993) The role of reduced nicotinamide adenine dinucleotide phosphate in glucose- and temperature-dependent doxorubicin cytotoxicity, Cancer Chemother. Pharmacol. 33, 191-196. 

Pethidine Hydrochloride Pethidine hydrochloride solutions are not compatible with barbiturates, aminophylline, morphine sulfate, sulfadiazine sodium, methicilline sodium, nitrofurantoin, phenytoin sodium, heparin sodium, sodium iodide, diethanolamine, sulfafurazol, acyclovir sodium, liposomal doxorubicin hydrochloride, frusemide, imipenem, and idarubicin. Visual incompatibilities are reported with mixtures of pethidine hydrochloride and cefoperazone sodium or mezlocillin sodium, nafcillin sodium and minocycline hydrochloride or tetracycline hydrochloride in 5% glucose injection.82 83... 

MDR (blocks efflux of Doxorubicin) T MDR-TR expression (Na+/glucose symport TR PKC) [AI] MDR-TR (mouse H,rNBD2 domain) [34] (cAMP PDE, COX, 5-LOX) [AI, APA, antifungal, inhibits basophil histamine release, pro-apoptotic]... 

Carbohydrates, commonly referred to as sugars and starches, are polyhydroxy aldehydes and ketones, or compounds that can be hydrolyzed to them. The cellulose in plant stems and tree trunks and the chitin in the exoskeletons of arthropods and mollusks are all complex carbohydrates. Four examples are shown in Figure 27.1. They include not only glucose and cellulose, but also doxorubicin (an anticancer drug) and 2 -deoxyadenosine 5 -monophosphate (a nucleotide base from DNA), both of which have a carbohydrate moiety as part of a larger molecule. 

These compounds illustrate the structural diversity of carbohydrates. Glucose is the most common simple sugar, whereas cellulose, which comprises wood, piant stems, and grass, is the most common carbohydrate in the piant world. Doxorubicin, an anticancer drug that has a carbohydrate ring as part of its structure, has been used in the treatment of ieukemia, Hodgkin s disease, and cancers of the breast, biadder, and ovaries. 2 -Deoxyadenosine 5 -monophosphate is one of the four nucieotides that form DNA. 

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