Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Gentamicin activity

Aminoglycoside antibiotic. Isol. from Micromonospora purpurea-nigrescens. Degradn. prod, of Gentamicin Active against gram-positive bacteria. Sol. H2O fairly sol. MeOH poorly sol. EtOH, hexane. Mg +102 (c, 1 in H2O). Copper, D.J. et al, J.C.S. (C), 1971, 3126 struct)... [Pg.522]

The white powder is a mixture of the sulfate of gentamicin Cja and the sulfate of XK-62-2, and exhibits an activity of 620 units/mg (the activity of 1 mg of pure product corresponds to 1,000 units). [Pg.1024]

C. Isolation and purification of XK-62-2 100 g of the white powder obtained in the above step B are placed to form a thin, uniform layer on the upper part of a 5 cm0X 150 cm column packed with about 3 kg of silica gel advancely suspended in a solvent of chloroform, isopropanol and 17% aqueous ammonia (2 1 1 by volume). Thereafter, elution is carried out with the same solvent at a flow rate of about 250 ml/hour. The eluate is separated in 100 ml portions. The active fraction is subjected to paper chromatography to examine the components eluted. XK-62-2 is eluted in fraction Nos. 53-75 and gentamicin Cja is eluted in fraction Nos. 85-120. The fraction Nos. 53-75 are combined and concentrated under reduced pressure to sufficiently remove the solvent. The concentrate Is then dissolved in a small amount of water. After freeze-drying the solution, about 38 g of a purified preparate of XK-62-2 (free base) is obtained. The preparate has an activity of 950 units/mg. Likewise, fraction Nos. 85-120 are combined and concentrated under reduced pressure to sufficiently remove the solvent. The concentrate is then dissolved in a small amount of water. After freeze-drying the solution, about 50 g of a purified preparate of gentamicin Cja (free base) is obtained. [Pg.1024]

Erythromycin is considered the optimal drug for treatment of Campylobacter infections. The rate of resistance of Campylobacter to erythromycin remains low. Other advantages of this drug include ease of administration, low cost, lack of major toxicity, and narrow spectrum of activity.14 The recommended dosage for adults is 250 mg orally four times daily or 500 mg orally twice daily for 5 to 7 days. For very ill patients, treatment with gentamicin, imipenem, cefotaxime, or chloramphenicol is indicated, but susceptibility tests should be performed. [Pg.1121]

The in vivo protective activity of rifaximin was studied in mice, infected experimentally by intraperitoneal inoculation of S. aureus Colliva and compared to that of rifampicin (a systemic rifamycin) and gentamicin (a poorly absorbed aminoglycoside) [74]. After oral administration, only rifampicin was effective whereas the other two compounds were inactive at doses up to 10 mg/kg. However, when injected subcutaneously, rifaximin displayed a good therapeutic efficacy (table 2). While confirming its antibacterial activity, these results clearly indicate that rifaximin, like gentamycin, is poorly absorbed after oral administration. [Pg.42]

The answer is a. (Hardman, pp 1105-1108.) The activity of streptomycin is bactericidal for the tubercle bacillus organism. Other aminoglycosides (e.g., gentamicin, tobramycin, neomycin, amikacin, and kanamycin) have activity against this organism but are seldom used clinically because of toxicity or development of resistance. [Pg.76]

Gentamicin and tobramycin are equally effective gentamicin is less expensive. Tobramycin has better pseudomonal activity, which may be important in serious systemic infections. Amikacin generally is reseived for multiresis-tant bacteria. [Pg.560]

Blepharitis is a topical inflammation of the eyelid margins that should be treated using topical antibacterial agents. Gentamicin eye ointment is preferred to the fusidic acid drops since the ointment is a better formulation to be used where the condition involves the eyelid margins. Chloramphenicol eye drops is the third option since it is an antibiotic with a wider spectrum of activity. A combination of corticosteroid and antibiotic is not recommended because of the side-effects associated with the steroid. The use of oral tablets is not usually recommended since blepharitis can easily be managed with topical drops. The use of dexamethasone eye drops, monotherapy steroid, could clear the inflammation but mask persistence of infection. [Pg.341]

The solution structures of 1 1 complex between paromomycin and gentamicin Cla and the A-site oligonucleotide have been solved at high resolution using heteronuclear NMR techniques These approaches require the preparation of uniformly labeled N- and C-RNA oligonucleotides via in vitro transcription with labeled nucleoside triphosphates. The use of RNAs labeled with NMR-active nuclei allows for the application of sophisticated heteronuclear NMR methods. These methods facilitate the assigmnent of NMR resonances and the acquisition of structural restraints for detailed structure determinations. [Pg.189]


See other pages where Gentamicin activity is mentioned: [Pg.26]    [Pg.481]    [Pg.483]    [Pg.483]    [Pg.484]    [Pg.484]    [Pg.484]    [Pg.530]    [Pg.108]    [Pg.134]    [Pg.703]    [Pg.1101]    [Pg.1191]    [Pg.542]    [Pg.77]    [Pg.422]    [Pg.341]    [Pg.4]    [Pg.72]    [Pg.72]    [Pg.145]    [Pg.399]    [Pg.115]    [Pg.210]    [Pg.245]    [Pg.604]    [Pg.31]    [Pg.5]    [Pg.7]    [Pg.8]    [Pg.8]    [Pg.131]    [Pg.135]    [Pg.189]    [Pg.192]    [Pg.239]    [Pg.249]    [Pg.256]    [Pg.260]    [Pg.25]   
See also in sourсe #XX -- [ Pg.30 , Pg.180 ]




SEARCH



Gentamicin antibacterial activity

Gentamicin structure-activity relationship

Pseudomonas aeruginosa gentamicin activity

© 2024 chempedia.info