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Gentamicin structure-activity relationship

Many other antibiotic compounds have also been isolated from the genus Streptomyces, all of which are closely related in structure to streptomycin. Six of them are currently in use in the United States kanamycin, neomycin, paromomycin, gentamicin, tobramycin, and netilmicin. All of these compounds exhibit at least one aminohexose in their structure, and extensive research on the relationship between structure and activity indicates that at least one amino sugar is necessary for antibiotic activity. As shown, kanamycin and neomycin both contain two amino sugars. [Pg.1170]


See other pages where Gentamicin structure-activity relationship is mentioned: [Pg.256]    [Pg.342]    [Pg.99]   


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