Pseudomonas aeruginosa gentamicin activity

It belongs to family nebramycins, is isolated from Streptomyces tenebrarius. Its antibacterial activity is similar to gentamicin and slightly more active than gentamicin against Pseudomonas aeruginosa and Proteus. 

It is semisynthetic derivative of kanamycin. It is active against gentamicin resistant organisms e.g. Pseudomonas aeruginosa, Klebsiella, E. coli and Proteus. It is resistant to bacterial aminoglycoside inactivating enzymes. 

Tobramycin is similar to gentamicin it is more active against most strains of Pseudomonas aeruginosa and may be less nephrotoxic. It is commonly administered via a nebulizer for treatment of infective exacerbations of cystic fibrosis caused by pseudomonads or Enlerobacteriaceae. 

Briefly, Tinospora cordifolia reduced mortality associated with intra-abdominal sepsis following caecal ligation. Thus, as compared to a mortality of 66 100% on the fifth day after surgery in untreated rats, 15 days of pretreatment with Tinospora cordifolia alone reduced mortality to 33% and further to 16.6% when combined with metronidazole and gentamicin [19]. This effect was reported to be associated with improved macrophage function. Furthermore, the aqueous extract of Tinospora cordifolia was found to be devoid of in vitro antimicrobial activity against Bacillus subtilis, Bacillus cereus Staphylococcus aureus Pseudomonas aeruginosa and Escherichia coli. Sera obtained from rats (n = 10 each) orally treated with the aqueous extract of Tinospora cordifolia in doses of 100 and 200 mg/kg were also found to have no antibacterial activity [19]. These data further indicated that Tinospora cordifolia was effective in infections due to its immunostimulant effects. 

Carbenidllin is used by itself or in combination with gentamicin for the treatment of infections by sensitive strains of Pseudomonas aeruginosa. The replacement of the phenyl moiety with 3-thienyl groups to produce ticarcillin leads to an increase in antipseudomonal activity. However, the carboxy penidllins show diminished activity against streptococci and enterococd due to reduced binding to the PBPs. 

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