Genome, simian virus

Woynarowski JM, Beerman TA (1997) Effects of bizelesin (U-77,779), a bifunctional alkylating minor groove binder, on repUcation of genomic and simian virus 40 DNA in BSC-1 cells. Biochim Biophys Acta 1353 50-60... 

Cleavage sites for restriction enzymes occur randomly in the DNA. The frequency of a particular restriction site is dependent on the size of the DNA and the size of the recognition sequence. The probability of finding a particular four-base run in DNA is 1/256 (l/4>base-specific restriction sites in the 5243 base pair, circular genome of the simian virus SV40 is shown in Table 2.7. 

The outcome of infection of cells by simian virus 40 depends on the nature of the cells. When primate cells are infected, the large-T protein is produced, and its presence ultimately leads to the production of new viral DNA and coat proteins. New virus particles are assembled and released the death of the host cell takes place when the new virions are released. When rodent cells are infected, the viral genome is incorporated into the cell DNA. (Adapted from Dealing with Genes The Language of Heredity, by Paul Berg and Maxine Singer, 1992 by University Science Books.)... 

Segment of the simian virus 40 (SV40) genome that contains an origin of replication plus a powerful promoter sequence. 

Gelb, L. D., Kohne, D. E., Martin, M. A. Quantitation of simian virus 40 sequences in African green monkey, mouse, and virus-transformed genomes. J. molec. Biol. 57,... 

Goujon, C., L. Jarrosson-Wuilleme, et al. 2003. Heterologous human immunodeficiency virus type 1 lentiviral vectors packaging a simian immunodeficiency virus-derived genome dis-... 

Type I and II (HTLV I and II) are two closely related types with a high genomic similarity, tropic for CD4+ T-lymphocytes. HTLV I is associated with the adult T-cell lymphoma and leukemia in addition to some types of myelopathy. HTLV II might be involved in certain demyelinating diseases. HTLV-III has similarity to the Simian T-lymphotropic virus 3 (STLV-III)... 

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