Genital formation

Even in adults, hormones have dramatic effects on genital formation. Women who take hormones or other medications as part of a deliberate female-to-male transition usually experience dramatic growth of the clitoris. Use of anabolic steroids by female body-builders and female athletes can also cause marked enlargement of the clitoris together with other effects that masculinize the female body. 

Baba, K. Takeshita, A. Majima, K. Ueda, R. Kondo, S. Jimi, N. Yamamoto, D. The Drosophila Bruton s tyrosine kinase (Btk) homolog is required for adult survival and male genital formation. Mol. Cell. Biol., 19, 4405-4413 (1999)... 

Formation of papules, bullae, or ulceration Excessive oozing Presence of genital discharge Concurrent fever... 

Haemophilus ducreyi, a gram-negative bacterium, has been isolated as the causative organism of chancroid, a genital ulcerative disease usually accompanied by inguinal lymphadenitis and bubo formation. Chancroid may possibly spread to other anatomic sites, a clinical feature first discovered by Ducrey in 1889.37... 

Oral acyclovir is useful in the treatment of HSV-1 and HSV-2 infections, such as genital herpes, herpes encephalitis, herpes keratitis, herpes labialis, and neonatal herpes. In initial episodes of genital herpes, oral acyclovir has been found to reduce viral shedding, increase the speed of healing of lesions, and decrease the duration of pain and new lesion formation. Acyclovir appears to be less effective in the treatment of recurrent herpes genitalis but may be used for the long-term suppression of recurrent HSV. 

DEFICIENCY in uiero, results in failure of male genital development. Deficiency in childhood results in failure to develop secondary male characteristics. This may be due to castration or a hypofunctioning hypotlialamus. In male pseudohermaphroditism, there appears to be a defect in the cellular recognition proteins for androgens, so that androgens, while present, do not stimulate the formation of male characteristics. 

Urolithiasis In vitamin A deficiency, urino-genital epithelium shows keratinization followed by bacterial invasion and formation of alkaline urine. This factors cause calcium phosphate precipitation, which leads to formation of urinary calculi. 

Copper-containing intrauterine contraceptive devices (10-12) became popular because local inflammatory reactions in the endometrium are more marked and the contraceptive effect is thus more pronounced (SEDA-21, 234) (13). In addition, copper ions released from intrauterine contraceptive devices reach concentrations in the luminal fluids of the genital tract that are toxic to spermatozoa and embryos. The ability of copper to induce the generation of free radicals and the formation of malonaldehyde may be involved in its contraceptive effect. 

In genital herpes, oral acyclovir (200 mg every 4 hours, 5 times daily for 10 days) reduces the duration of acute infection, attenuates pain and new lesion formation, and... 

The fetal testis induces a male type of phenotypic sex development by virtue of producing two sorts of hormones. The first of these is the androgen testosterone, which triggers the formation of male structures from the Wolffian duct, the urogenital sinus, and the external genital primordia, via mechanisms considered below. The second type of fetal testicular hormone is a macromolecule, apparently a glycoprotein, that evokes involution of the Mullerian duct during normal male sex differentiation. 

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