Genetics single nucleotide polymorphisms

Analysing single nucleotide polymorphisms to hunt for genetic sources of diseases... 

Single Nucleotide Polymorphisms (SNPs) are single base pair positions in genomic DNA at which normal individuals in a given population show different sequence alternatives (alleles) with the least frequent allele having an abundance of 1% or greater. SNPs occur once every 100-300 bases and are hence the most common genetic variations. 

SNP Single nucleotide polymorphism. Refers to the fact that single nucleotide genetic variation in genome sequence exists at discrete loci throughout the chromosomes. Measurement of allelic SNP differences is useful for gene mapping studies. 

Genetic data also support a role for CCR2 in atherosclerosis. The human CCR2 gene has a single nucleotide polymorphism (SNP) that results in a Val... 

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Gray IC et al. Single nucleotide polymorphisms as tools in human genetics. Hum Mol Genet 2000 9 2403-2408. 

Marth G, Yeh R, Minton M, Donaldson R, Li Q, Duan S, Davenport R, Miller RD, Kwok PY. Single-nucleotide polymorphisms in the public domain how useful are they Nature Genet 2001 4 371-372. 

Iida A, Sekine A, Saito S, Kitamura Y, Kitamoto T, Osawa S, Mishima C, Nakamura Y. Catalog of 320 single nucleotide polymorphisms (SNPs) in 20 qui-none oxidoreductase and sulfotransferase genes. J Hum Genet 2001 46 225-240. 

Seki T, Tanaka T, Nakamura Y. Genomic stmcture and multiple single-nucleotide polymorphisms (SNPs) of the thio-purine S-methyltransferase (TPMT) gene. J Hum Genet 2000 45 299-302. 

Ohnishi Y, Tanaka T, Yamada R, Sue-matsu K, Minami M, Fujii K, Hoki N, Kodama K, Nagata S, Hayashi T, Ki-noshita N, Sato H, Sato H, Kuzuya T, Takeda H, Hori M, Nakamura Y. Identification of 187 single nucleotide polymorphisms (SNPs) among 41 candidate genes for ischemic heart disease in the Japanese population. Hum Genet 2000 106 288-292. 

Genetic Association Analysis Using Single Nucleotide Polymorphisms (SNPs)... 

Martin ER, Lai EH, Gilbert JR et al. SNPing away at complex diseases analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. Am J Hum Genet 2000 67 383-394. 

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Allele One form of a genetic locus, distinguished from other forms (= alleles) by its particular nucleotide or its coded amino acid sequence. Single nucleotide polymorphisms are biallelic, i.e., one base pair is exchanged with just one other base pair. In such a case, only two different alleles exist in the population for such a gene locus. However, several different alleles may exist in the population if the locus is defined by more than one nucleotide (i.e., microsatelhtes, haplotypes). Thus,... 

Chen, X. and Kwok, P. Y. (1999). Homogeneous genotyping assays for single nucleotide polymorphisms with fluorescence resonance energy transfer detection. Genet. Anal. 14, 157-63. 

T. Sakata and Y. Miyahara, Potentiometric detection of single nucleotide polymorphism by using a genetic field-effect transistor. ChemPhysChem. 6, 703-710 (2005). 

Single nucleotide polymorphism (SNP) is a variation of the genetic sequence (point mutation) when a single nucleotide in the DNA is altered. It has a 0.1% chance of... 

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