Coding Region

Exons are protein-coding regions that mu.st be joined by removing introns, die noncoding intervening. sequences. 

RNA decoys from HCV stem-loop structures in NS5B coding region sequester replication complexes HCV (Zhang et al. 2005)... 

Dias N., Dheur S., Nielsen P.E., Gryaznov S., Van Aerschot A., Herde-wijN P., Helene G., Saison-Behmoaras T. E. Antisense PNA tridecamers targeted to the coding region of Ha-ras mRNA arrest polypeptide chain elongation. J. Mol. Biol. 1999 294 403-416. 

In contrast to most mRNAs, which become untranslatable after a temperature downshock, cold shock mRNAs possess a mechanism to form the translation initiation complex at low temperature without cold shock ribosomes. A close inspection of the mRNAs of class I cold shock proteins reveal that they are equipped with an extra ribosome-binding site called the downstream box located within the coding region of their transcript [130]. It would be interesting to know whether introduction of this downstream box into a cellular mRNA would convert it into a transcript which can be transcribed immediately after a cold shock. In the case of the cspA mRNA it has been shown that in the absence of the downstream box the initiation complex cannot be formed at low temperature during the accHmation phase [131]. 

Coding Regions Are Often Interrupted by Intervening Sequences... 

The protein coding regions of DNA, the transcripts of which ultimately appear in the cytoplasm as single mRNA molecules, are usually interrupted in the eukaryotic genome by large intervening sequences of... 

Figure 39-19. Structure of a typical eukaryotic mRNA showing elements that are involved in regulating mRNA stability. The typical eukaryotic mRNA has a 5 noncoding sequence (5 NCS), a coding region, and a 3 NCS. All are capped at the 5 end, and most have a polyadenylate sequence at the 3 end. The 5 cap and 3 poly(A) tail protect the mRNA against exonuclease attack. Stem-loop structures in the 5 and 3 NCS, features in the coding sequence, and the AU-rich region in the 3 NCS are thought to play roles in mRNA stability.

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