Genes and diseases

The struggle for existence continues at whole body, cellular, and molecular levels. Plant and animal species survive hy producing the most offspring. Plants launch thousands of seeds. Some have stickers that attach themselves to the feet and legs of passing animals, making it possible for them to survive and reproduce. [Pg.9]

Genes are DNA sequences that are copied by the action of the enzyme RNA polymerase, and are passed on by transfer RNA to ribosomes, where proteins are synthesized in a process called translation. Ribosomes assemble amino acids into polypeptide chains messenger RNA provides a template to join together the correct sequence of amino acids. [Pg.9]

DNA and RNA can be radiolabeled with carbon-14,hydrogen-3,or phosphorus-32 and then separated into their constituent nucleotide sequences by enzymatic digestion. Restriction enzymes cut double-stranded DNA through each of the sugar-phosphate backbones, without damaging the nucleotide bases. [Pg.9]

In the millions of nucleotides in the segments that make up molecules of DNA, there are millions of differences in the nucleotide sequences between any two persons. It is possible to determine which segments are inherited from which parent Some fragments have been correlated with specific diseases in a process called genetic linkage. [Pg.9]

Genetic linkage maps show the relative locations of specific markers along a chromosome. A marker may be related to a trait, such as the Lesch-Nyhan syndrome. Restriction fragment length polymorphisms and specific DNA sequences, called sequence-tagged sites, are markers that make it possible to identify persons with a specific disease. [Pg.9]

Genes and Disease http //www.ncbi.nlm.nih.gov/disease/ (Coverage of the genetic basis of many different types of diseases.) The Glycoscience Network (TGN) http //www.vei.co.uk/TGN/ tgn side.htm... [Pg.639]

Pharmacogenomic studies are often carried out in the context of clinical trials which, by virtue of having both a treatment and placebo group, are able to assess the association between a gene and disease progression independent of therapy as well as interactive effects of genotypes and therapy on disease. Several of the phar-... [Pg.52]

Lamb, J., Crawford, E.D., Peck, D., et al. (2006) The Connectivity Map using gene-expression signatures to connect small molecules, gene, and disease. Science, 313, 1929-1935. [Pg.339]

Lamb J, Crawford ED, Peck D et al. The Cormeetivity Map using gene-expression signatures to cormect small molecules, genes, and disease. Science 2006 313 1929-1935. [Pg.350]

Program of Genes and Diseases, Center for Genomic Regulation, Barcelona, Spain... [Pg.611]

The facilitation of new drugs with specific targeting, based on the proteins, enzymes and RNA molecules associated with genes and diseases. [Pg.286]

Lamb J (2006) The connectivity map Using Gene-Expression Signatures to Connect Small Molecules, Genes and Disease. Science 313 1929-1935... [Pg.9]

Boncinelli, E. (1997) Homeobox genes and disease . Current Opinion in Genetics and Development, 7, 331-7. [Pg.27]

Blasi F (ed) (1986) Human Genes and Diseases, Vol 8 in Horizons in Biochemistry and Biophysics. Chichester Wiley. [Pg.110]

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