General points to consider

In this chapter not only the topic of water-soluble salts but also some general points to consider when the final form of a drug substances will be decided upon. Although it is generally accepted that solubility in aqueous media is the most crucial physicochemical property of a drug substance, it is not appropriate that only a single parameter should dominate such an important decision. Since here only... 

General points to consider when using oxidants to oxidize organic pollutants in soil are that an elevated temperature always results in a higher reaction rate and that most reactions that use oxidants for the production of radicals need a special minimum temperature to work. In some cases, temperatures that are too low can be compensated for by using catalysts such iron salts for the production of radicals. 

Zinc coatings are used primarily to protect ferrous parts against atmospheric corrosion. These coatings have good resistance to abrasion by solid pollutants in the atmosphere. General points to consider are ... 

CPMP (2002) Points to Consider on Multiplicity Issues in Clinical Trials General aspects of multiple testing were considered in this guideline together with discussion on adjustment of significance levels or specific circumstances where adjustment is not needed (see Chapter 10). 

This is an important point to consider however, there is no general consensus as yet. 

Generally the indoor environment allows different chemical transformation reactions to occur than usually predominate in the outside atmosphere. So called night-time chemistry (atmospheric chemical reactions not driven by photochemistry) is usually a good starting point to consider the in-museum chemistry that goes on. 

Tissue banks are the most common source of human tissues. While surgical biopsy accessions are preferred, they are limited in availability and often unavailable for many tissues (e.g., brain and other vital organs). Therefore the majority of tissue samples used in cross-reactivity studies are those acquired at autopsy. For autopsy accessions all efforts must be made to minimize the time interval between death and tissue collection. Information provided with specimens generally includes age, gender, and usually race and some clinical history and/or cause of death. As suggested in the Points-to-Consider document, the tissues used in a standard tissue cross-reactivity study are acquired from adults (>18 years of age). Pediatric tissues are often very difficult to obtain and are usually not used in a standard tissue cross-reactivity study unless there is a clear pediatric indication for the test article. 

There are thus three fixed points to consider in the testing of fireclays or for that matter in the examination of refractories in general, viz., the vitrification temperature at which the mass becomes dense and practically impervious, the point at which it becomes overfired and vesicular and the softening temperature. The difference between the vitrification and overfiring temperature constitutes the vitrification range which is of considerable technical importance from the manufacturing standpoint. 

Figure 22 General list of points to consider in the validation plan for a computerised system...

Despite the steady course of history in favor of mosfets in general, there still remain some arguments for continuing to prefer bjts in certain applications. Some points to consider and debate here are ... 

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