General Hints

Emphasis has to be on choice and proper handling of the mobile phase. In Chapter 4 different approaches for mobile phase selection are discussed. General hints for selection are the avoidance of the following ... 

The mechanism of these AOPs was already described in Chapter A 2, the importance and influence of various parameters affecting the oxidation process was discussed in Section B 4.4. The goal of the following section is to give some examples of existing processes and some general hints for the application of AOP. 

The above are general hints only, to which, for the expert gatherer, there will be many exceptions. 

Some general hints may further assist the decision on which family to select. Certainly each single method will have its own special usefulness or its own prerequisites or conditions of application. 

A suggestion of necessary types of radiokinetic studies and general hints for conducting those animal ADME studies can be found in Campbell DB, Jochemsen R (1994). 

The example shown comprises protein-binding in vitro only (pre-dose samples), since the parent compound in plasma was known massively to exceed all metabolites. If this is not the case, additional samples to determine the protein binding ex vivo are required. Depending on the kind of measurement (radioactivity vs. specific), these samples can then indicate a general hint for protein binding across all labeled molecules (weighted by their occurrence in plasma), if only the ex-vivo radioactivity is determined, or can provide protein binding data for metabolites, if a specific assay is available. 

General Hints. You need to refer to a table of atomic weights, which you will find in the catalogues of the major chemical suppliers. 

Although both carbon and silicon are in Group 4A, very few Si=Si bonds are known. Account for the instability of silicon-to-silicon double bonds in general. Hint Compare the atomic radii of C and Si in Figure 8.5. What effect would the larger size have on pi bond formation )... 

Practical HPLC Methodology and Applications Practical HPLC Method development (Both the last ones are suitable for careful study of a method development and optimization.) Troubleshooting HPLC Systems, a Bench Manual (general hints, maintenance and troubleshooting of the HPLC equipment). 

These are the most important definitions. Before the detailed presentation is given on how the suitable addition of a chemically inert gas can convert an explosible atmosphere into one which does not hold this risk any more, some general hints shall be provided regarding the assessment strategy of an explosion risk. 

Before getting started, we should take some time to carefully choose our monomers and template for the initial experiment (so called building blocks in Chapter 7 of this book). Here are some general hints. The readers should also consult Chapters 14 and 16 for discussions on the topic. 

There are no rigid rules for the interpretation of infrared or Raman spectra. However, a few general hints may be given. 

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