Troubleshooting HPLC Systems

In HPLC it is inevitable that something will break down at some time because so many interactions are taking place within the chromatographic process— not to mention the many moving parts within the HPLC instrument. It is tempting to dive in and try to fix the problem. However, a word of caution You might do more harm than good. Every action needs to be documented and monitored carefully to ensure quality compliance and to ensure that future results are reliable and accurate. [Pg.187]

The scope of this chapter is limited to troubleshooting HPLC systems using predeveloped and validated methods of analysis. We will focus on some of the most commonly encountered problems and the possible solutions. [Pg.187]

In order to understand the problem, it is necessary to understand how each of the components functions in the HPLC system and the chromatographic processes that are taking place. The main components that make up the HPLC system have been explained in Chapter 2, namely [Pg.187]

P.C. Sadek, Troubleshooting HPLC Systems A Bench Manual, Wiley-Interscience, New York, 1999. ISBN 0471178349. [Pg.49]

The following is a set of guidelines and strategies for troubleshooting HPLC system problems. Further details on HPLC troubleshooting can be found elsewhere. [Pg.264]

Runser, D. J., Maintaining and Troubleshooting HPLC Systems A User s Guide, Wiley New York, (1981). [Pg.650]

Sadek PC. Troubleshooting HPLC systems A bench manual. New York Whey-Interscience, 1999 306pp. [Pg.163]

Practical HPLC Methodology and Applications Practical HPLC Method development (Both the last ones are suitable for careful study of a method development and optimization.) Troubleshooting HPLC Systems, a Bench Manual (general hints, maintenance and troubleshooting of the HPLC equipment). [Pg.168]

Dolan JW and Snyder LR (1989) Troubleshooting HPLC Systems. Clifton, NJ Humana Press. [Pg.2533]

Sadek PC (2000) Troubleshooting HPLC Systems. New York WUey Sons. [Pg.2533]

Dolan, J.W. Snyder, L.R. Troubleshooting HPLC Systems A Comprehensive Approach to Troubleshooting LC Equipment and Separations, Humana Press Totowa (U.S.A.), 1989 165-200. [Pg.1961]

Runser D J 1981 Maintaining and troubleshooting HPLC systems. John Wiley New York, 176 pp... [Pg.121]

Sadek, P.C. Troubleshooting HPLC Systems. A Bench Manual, John Wiley Sons, New York, 2000. [Pg.738]

I have attempted to address these needs in two other texts— through method review and summary in The HPLC Solvent Guide, 2nd edition, and through description of the use and maintenance of LCs in Troubleshooting HPLC Systems A Bench Manual. [Pg.1]

Sadek, P. C. (2000). Troubleshooting HPLC Systems A Benchmark Manual, Wiley, New York. [Pg.233]

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