Gene synthetase

Sosio M, Elossi E, Bianchi A, Donadio S (2000) Multiple gene synthetase gene dusters in actinomycetes. Mol Gen Genet 264 213-221 Stachelhaus T, Schneider A, Marahiel M (1995) Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains. Sdence 269 69—71... 

Boylan, M., etal. (1989). Lux C, D and E genes of the Vibrio fischeri luminescence operon code for the reductase, transferase and synthetase enzymes involved in aldehyde biosynthesis. Photochem. Photobiol. 49 681-688. 

Gene activated Lipoprotein lipase fatty acid transporter protein adipocyte fatty acid binding protein acyl-CoA synthetase malic enzyme GLUT-4 glucose transporter phosphoenolpyruvate carboxykinase... 

Fatty acid transport protein paralogues 1-6 FATP 1-6 Gene symbols SLC27A1-6 Solute carrier family 27A Very long-chain acyl-CoA synthetase VLCS... 

Sierra-Rivera, E., Summer, M. L., Dasouki, M., Krishnamani, M. R. S Phillips, J. A., and Freeman, M. L., Assignment of the human gene (GLCLR) that encodes the heavy subunit of y-glu-tamylcysteine synthetase to chromosome 6. Cytogenet. Cell. Genet. 70,278-279 (1995). 

Lamour V., Quevillon, S., Diriong, S., N Guyen, V. C., Lipinski, M. and Miranda, M. (1994), Evolution of the Glx-tRNA synthetase family the glutaminyl enzyme as a case of horizontal gene transfer , Proc. Natl. Acad. Sci. USA, 91, 8670. 

Herrmann, T., et al. Mouse fatty acid transport protein 4 (FATP4) characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase. Gene 2001, 270,... 

The molecular basis by which interferons promote their characteristic effects, in particular antiviral activity, is understood at least in part. Interferon stimulation of the JAK-STAT pathway induces synthesis of at least 30 different gene products, many of which cooperate to inhibit viral replication. These antiviral gene products are generally enzymes, the most important of which are 2 -5 oligoadenylate synthetase (2,5-A synthetase) and the eIF-2a protein kinase. 

Several active forms of the synthetase seem to be inducible in human cells 40 kDa and 46 kDa variants have been identified that differ only in their carboxy terminus ends. They are produced as a result of differential splicing of mRNA transcribed from a single gene found on chromosome 11. A larger 85-100 kDa form of the enzyme has been detected, which may represent a heterodimer composed of the 40 and 46 kDa variants. 

Moffitt MC, Neilan BA (2004) Characterization of the nodularin synthetase gene cluster and proposed theory of the evolution of cyanobacterial hepatotoxins. Appl Environ Microbiol... 

Aside from these relatively direct applications of site-directed mutagenesis, combination of recombinant DNA techniques with other experimental strategies will no doubt prove to be of increasing importance. If the gene of interest can be expressed with sufficient efficiency in auxotrophs, then proteins in which selected amino acids are isotopically enriched [12] may be produced to increase the sensitivity and selectivity of magnetic resonance techniques. Alternatively, amino acid analogues that are recognized as substrates by aminoacyl tRNA synthetases may be incorporated randomly in place of the true substrate amino... 

Lin SJ, Defossez PA, Guarente L (2000) Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289 2126—2128 Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 137-148 Mabley JG, Suarez-Pinzon WL, Hasko G, Salzman AL, Rabinovitch A, Kun E, Szabo C (2001) Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-l,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes. Br J Pharmacol 133 909-919... 

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