Adipocyte fatty acid-binding protein

Gene activated Lipoprotein lipase fatty acid transporter protein adipocyte fatty acid binding protein acyl-CoA synthetase malic enzyme GLUT-4 glucose transporter phosphoenolpyruvate carboxykinase... 

Herr, F.H., Matarese, V., Bernlohr, D.A. and Storch, J. (1995) Surface lysine residues modulate the collisional transfer of fatty acid from adipocyte fatty acid binding protein to membranes. Biochemistry 34, 11840-11845. 

Hotamishgil, G S., et al., Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science, 1996, 274, 1377-1379. 

The FABPs are a family of carrier proteins for fatty acids and other lipophilic substances, such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. Adipocyte fatty acid-binding protein (aP2 FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Studies in aP2-deflcient mice have shown that this lipid chaperone has a significant role in several aspects of the metabolic syndrome, including type 2 diabetes and atherosclerosis. FABP has also been introduced as a plasma marker of acute myocardial infarction. 

Perrella MA, Pellacani A, Layne MD, Patel A, Zhao D, Schreiber BM, Storch J, Feinberg MW, Hsieh CM, Haber E, Lee ME (2001) Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J 15 1774-1776... 

S. Shaughnessy, E.R. Smith, S. Kodu-KULA, J. Storch, and S.K. Fried, Adipocyte metabolism in adipocyte fatty acid binding protein knockout (aP2—/—) mice after short-term high-fat feeding functional compensation by keratinocyte fatty acid binding protein. Diabetes, 2000, 49, 904-911. 

Choi, K. M., Yannakouba, M., Park, M. S. et al. 2011. Serum adipocyte fatty acid-binding protein, retinol binding protein 4, and adiponectin concentrations in relation to the development of the metabolic syndrome in Korean boys A 3-y prospective cohort study. Am J... 

Ortega-SenovUla, H., Schaefer-Graf, U., Meitzner, K. et al. 2011. Gestational diabetes mel-litus causes changes in the concentrations of adipocyte fatty acid-binding protein and other adipokines in cord blood. Diabetes Care 34 2061-2066. 

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