Gene expression regulators

Some of the materials and techniques used in molecular biology may attract royalties if used for commercial purposes. Vectors, host strains and off-the-shelf DNA manipulation methods are usually readily available for modest licence fees for research purposes, but additional licences would need to be sought (and fees paid) if these systems were used in a commercial process. Where commercial exploitation is planned, the researchers should be prepared to switch to royalty-free genetic systems and avoid the use of costly and potentially toxic materials, such as artificial inducers or substrates, as gene expression regulators. 

Wingender, E., Chen, X., Hehl, R., et al. (2000) TRANSFAC an integrated system for gene expression regulation. Nucleic Acids Res. 28, 316-319. 

Gene Expression Regulation, Plant. 4. Plant Extracts. 5. Technology, Pharmaceutical. 

Balmer JE, Blomhoff R. Gene expression regulation by retinoic acid./ Lipid Res 43 1773-1808, 2002. 

Care must be taken when choosing housekeeping genes for normalisation, as there are many citations reporting the gene expression regulation of all of these commonly used housekeepers. 

The cAMP pathway is thought to play an important role in the gene expression regulated by the dopamine receptors. Indeed, many treatments that induce gene expression in the striatum are also known to increase cAMP levels. In the model of 6-OHDA-lesioned animal, gene induction was triggered by D1 agonist treatments or by l-DOPA via D1... 

In this chapter, three applications how quantitative informations which are representative for cellular processes or single cell analysis like gene expression regulation,... 

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