Gene apoptosis-associated

MIL Messadi, D. V., Le, A., Berg, S., Jewett, A., Wen, Z., Kelly, R, and Bertolami, C. N., Expression of apoptosis-associated genes by htrman dermal scar fibroblasts. Wound Repair Regen. 7,511—517 (1999). 

Leaman DW, Chawla-Sarkar M,Vyas K, Reheman M,Tamai K,Toji S, and Borden EC. Identification of X-linked Inhibitor of Apoptosis-associated Eactor-1 as an Interferon-stimulated Gene That Augments TRAIL Apo2L-induced Apoptosis. J Biol Chem 277 28504-28511,2002. 

Rosenblum MD, Olasz E, Woodliff JE, Johnson BD, Konkol MC, Gerber KA, Orentas RJ, Sandford G, Truitt RL (2004) CD200 is a novel p53-target gene involved in apoptosis-associated immune tolerance. Blood, 103 2691-2698. 

Attardi LD, Reczek EE, Cosmas C et al. PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev 2000 14(6) 704-718. 

Decitabine (5-aza-deoxycytosine) is an analog of the nucleoside 2 -deoxycytidine. It is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and by inhibition of the enzyme DNA methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis. DNA hypomethylation is achieved at concentrations below those required to significantly inhibit DNA synthesis, which may promote restoration of function to genes associated with control of cellular differentiation and proliferation. Cytotoxicity in rapidly dividing cells may also result from covalent adducts between DNA methyltransferase and decitabine. 

Many of the agents currently in use for the therapy of cancer can trigger apoptosis in cancer cells. Cancer-associated alterations of the genes that regulate apoptosis would therefore be predicted to affect sensitivity to these agents. 

Radu CG, Cheng D, Nijagal A et al (2006) Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor. Mol Cell Biol 26 668-677... 

Ohnishi H, Asamoto M, Tujimura K, Hokaiwado N, Takahashi S, Ogawa K, et al. Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo. Cancer Sci 2004 95 936-42. 

A number of subtle dysfunctions occur at the cellular and molecular levels in the early stages of disease progression associated with the loss of cellular homeostatic functions of endothelial cells, smooth muscle cells and macrophages which constitute the major cell types in the atheroma environment. These events include the modification of the pattern of gene expression, cell proliferation and apoptosis. 

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