Interferon Stimulated Gene

All interferon-stimulated genes are characterized by the presence of an associated interferon-stimulated response element (ISRE). Signal transduction culminates in the binding of specific regulatory factors to the ISRE, which stimulates RNA polymerase Il-mediated transcription of the interferon-sensitive genes. The induced gene products then mediate the antiviral, immunomodulatory and other effects characteristically induced by interferons. 

Interferon-stimulated genes modulate many biological effects including inhibition of viral replication in infected cells, inhibition of cellular proliferation and immunomodulation... 

Fig. 10.5a). Differences in the length of spacers between TT and AA in the GAS-element are thought to be responsible for discrimination between different STAT transcription factors. Interferon-cc/p signals are transmitted through heterodimeric STAT 1/STAT 2, which form a complex with a protein, p48, and recruit ISGF3 (the interferon-stimulated gene factor 3), and address the interferon-stimulated response element (ISRE) (Fig. 10.5b). 

H. A. R Bluyssen, R Muzaffar, R. J. Vliestra, A. C. J. van der Made, S. Leung, G. R Stark, et al. Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses. Proc Natl Acad Set, USA, 92, 5645—5649, 1995. 

Pellagatti A, Cazzola M, Giagounidis AA et al. Gene expression profiles of CD34- - cells in myelo-dysplastic syndromes involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype. Blood 2006 108(l) 337-345. 

Chawla-Sarkar M, Lindner D, Liu Y, Williams B, Sen G, Silverman R, and Borden E. Apoptosis and interferons role of interferon-stimulated genes as mediators of apoptosis. Apoptosis 8 237-249, 2003. 

Leaman DW, Chawla-Sarkar M,Vyas K, Reheman M,Tamai K,Toji S, and Borden EC. Identification of X-linked Inhibitor of Apoptosis-associated Eactor-1 as an Interferon-stimulated Gene That Augments TRAIL Apo2L-induced Apoptosis. J Biol Chem 277 28504-28511,2002. 

Padovan, E., L. Terracciano, U. Certa, B. Jacobs, A. Reschner, M. Belli, G. C. Spagnoli, E. C. Borden, and M. Heberer. 2002. Interferon stimulated gene 15 constitutively produced by melanoma cells induces e-cadherin expression on human dendritic cells. Cancer Res 62 3453. 

Pebernard, S., R.D. Iggo. 2004. Determinants of interferon-stimulated gene induction by RNAi vectors. Differentiation 72, 103-111. 

Qureshi S. A., Salditt-Georgieff M., Darnell J. E., Jr (1995) Tyrosine-phosphorylated Statl and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated gene factor 3. Proc. Natl. Acad. Sci. USA 92 3829. 

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